Expression of LAPTM5 in cancer - Summary - The Human Protein Atlas

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LAPTM5

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LAPTM5
Gene description	Lysosomal protein transmembrane 5
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HEL, HMC-1, REH)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in several different tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Approved based on 1 antibody. HPA051293
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and cervical cancer (favourable).
Renal cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051293

GENE INFORMATION
Gene name	LAPTM5
Synonyms
Description	Lysosomal protein transmembrane 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a transmembrane receptor that is associated with lysosomes. The encoded protein, also known as E3 protein, may play a role in hematopoiesis. [provided by RefSeq, Feb 2009]
Chromosome	1
Cytoband	p35.2
Chromosome location (bp)	30732469 - 30757820
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162511 (version 83.38)
Entrez gene	7805
UniProt	Q13571 (UniProt - Evidence at protein level)
neXtProt	NX_Q13571
Antibodypedia	LAPTM5 antibodies

PROTEIN BROWSER

LAPTM5-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LAPTM5-001 ENSP00000294507 ENST00000294507	Q13571 [Direct mapping] Lysosomal-associated transmembrane protein 5 Q5TBB8 [Target identity:100%; Query identity:100%] Lysosomal associated multispanning membrane protein 5, isoform CRA_a; Lysosomal multispanning membrane protein 5; cDNA FLJ75768, highly similar to Homo sapiens lysosomal associated multispanning membrane protein 5 (LAPTM5), mRNA Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0016021 [integral component of membrane] Show all	262 aa 29.9 kDa	No	5

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.