Expression of MXRA8 in cancer - Summary - The Human Protein Atlas

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MXRA8

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MXRA8
Gene description	Matrix-remodelling associated 8
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (BJ, BJ hTERT+)
HPA (normal tissue):	Tissue enhanced (adipose tissue)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA053958 , HPA055780
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), urothelial cancer (unfavourable) and stomach cancer (unfavourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Stomach cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA053958	HPA055780

GENE INFORMATION
Gene name	MXRA8 (HGNC Symbol)
Synonyms	DKFZp586E2023
Description	Matrix-remodelling associated 8 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p36.33
Chromosome location (bp)	1352689 - 1361777
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162576 (version 83.38)
Entrez gene	54587
UniProt	Q9BRK3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BRK3
Antibodypedia	MXRA8 antibodies

PROTEIN BROWSER

MXRA8-001	MXRA8-002	MXRA8-003	MXRA8-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MXRA8-001 ENSP00000307887 ENST00000309212	Q9BRK3 [Direct mapping] Matrix-remodeling-associated protein 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0060857 [establishment of glial blood-brain barrier] GO:0070062 [extracellular exosome] Show all	442 aa 49.1 kDa	Yes	1
MXRA8-002 ENSP00000436135 ENST00000477278	Q9BRK3 [Direct mapping] Matrix-remodeling-associated protein 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0060857 [establishment of glial blood-brain barrier] GO:0070062 [extracellular exosome] Show all	433 aa 48 kDa	Yes	1
MXRA8-003 ENSP00000399229 ENST00000445648	Q9BRK3 [Direct mapping] Matrix-remodeling-associated protein 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0060857 [establishment of glial blood-brain barrier] GO:0070062 [extracellular exosome] Show all	450 aa 49.6 kDa	Yes	1
MXRA8-201 ENSP00000344998 ENST00000342753	Q9BRK3 [Direct mapping] Matrix-remodeling-associated protein 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0060857 [establishment of glial blood-brain barrier] GO:0070062 [extracellular exosome] Show all	341 aa 38.1 kDa	Yes	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.