Expression of FAAP20 in cancer - Summary - The Human Protein Atlas

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FAAP20

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FAAP20
Gene description	Fanconi anemia core complex associated protein 20
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in selected tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification. Sub cellular location is contradicted by external data.
Reliability score	Uncertain based on 1 antibody. HPA038829
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable) and liver cancer (unfavourable).
Pancreatic cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Pancreatic cancer

STAINING SUMMARY

HPA038829

GENE INFORMATION
Gene name	FAAP20 (HGNC Symbol)
Synonyms	C1orf86, FLJ31031
Description	Fanconi anemia core complex associated protein 20 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p36.33
Chromosome location (bp)	2184461 - 2212720
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162585 (version 83.38)
Entrez gene	199990
UniProt	Q6NZ36 (UniProt - Evidence at protein level)
neXtProt	NX_Q6NZ36
Antibodypedia	FAAP20 antibodies

PROTEIN BROWSER

FAAP20-006	FAAP20-008	FAAP20-009	FAAP20-010	FAAP20-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAAP20-006 ENSP00000367804 ENST00000378543	Q6NZ36 [Direct mapping] Fanconi anemia core complex-associated protein 20 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0006281 [DNA repair] GO:0006974 [cellular response to DNA damage stimulus] GO:0019985 [translesion synthesis] GO:0030054 [cell junction] GO:0031593 [polyubiquitin binding] GO:0036297 [interstrand cross-link repair] GO:0043130 [ubiquitin binding] GO:0043240 [Fanconi anaemia nuclear complex] GO:0046872 [metal ion binding] GO:0070530 [K63-linked polyubiquitin binding] Show all	112 aa 11.8 kDa	No	0
FAAP20-008 ENSP00000367808 ENST00000378546	Q6NZ36 [Direct mapping] Fanconi anemia core complex-associated protein 20 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0006281 [DNA repair] GO:0006974 [cellular response to DNA damage stimulus] GO:0019985 [translesion synthesis] GO:0030054 [cell junction] GO:0031593 [polyubiquitin binding] GO:0036297 [interstrand cross-link repair] GO:0043130 [ubiquitin binding] GO:0043240 [Fanconi anaemia nuclear complex] GO:0046872 [metal ion binding] GO:0070530 [K63-linked polyubiquitin binding] Show all	180 aa 19.9 kDa	No	0
FAAP20-009 ENSP00000383709 ENST00000400918	Q6NZ36 [Direct mapping] Fanconi anemia core complex-associated protein 20 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0006281 [DNA repair] GO:0006974 [cellular response to DNA damage stimulus] GO:0019985 [translesion synthesis] GO:0030054 [cell junction] GO:0031593 [polyubiquitin binding] GO:0036297 [interstrand cross-link repair] GO:0043130 [ubiquitin binding] GO:0043240 [Fanconi anaemia nuclear complex] GO:0046872 [metal ion binding] GO:0070530 [K63-linked polyubiquitin binding] Show all	170 aa 18.7 kDa	No	0
FAAP20-010 ENSP00000409721 ENST00000420515	H7C361 [Direct mapping] Fanconi anemia-associated protein of 20 kDa Show all	Predicted intracellular proteins Show all		195 aa 21.5 kDa	No	0
FAAP20-201 ENSP00000383710 ENST00000400919	F6S8H2 [Direct mapping] Fanconi anemia-associated protein of 20 kDa Show all	Predicted intracellular proteins Show all		189 aa 20.5 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.