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DIRAS3

GENERAL INFORMATION

Gene name

 DIRAS3

Gene description

 DIRAS family, GTP-binding RAS-like 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (TIME, U-251 MG, U-87 MG)
HPA (normal tissue):Tissue enhanced (ovary)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several different tissue types at variable levels.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 3 antibodies.
HPA028483 , HPA028557 , HPA029384
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable) and renal cancer (favourable).
Breast cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Ovarian cancer

STAINING SUMMARY
HPA028483
HPA028557
HPA029384

GENE INFORMATION

Gene name

 DIRAS3 (HGNC Symbol)

Synonyms

 ARHI, NOEY2

Description

 DIRAS family, GTP-binding RAS-like 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the ras superfamily. This gene is imprinted gene with monoallelic expression of the paternal allele which is associated with growth suppression. The encoded protein acts as a tumor suppressor whose function is abrogated in many ovarian and breast cancers. This protein may also play a role autophagy in certain cancer cells by regulating the autophagosome initiation complex. [provided by RefSeq, Nov 2015]

Chromosome

 1

Cytoband

 p31.3

Chromosome location (bp)

 68045962 - 68051631

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162595 (version 83.38)

Entrez gene

 9077

UniProt

 O95661 (UniProt - Evidence at protein level)

neXtProt

 NX_O95661

Antibodypedia

 DIRAS3 antibodies

PROTEIN BROWSER
DIRAS3-001
DIRAS3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DIRAS3-001
ENSP00000360020
ENST00000370981
O95661 [Direct mapping]
GTP-binding protein Di-Ras3
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   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
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GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
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 229 aa
25.9 kDa 		No 0
DIRAS3-201
ENSP00000378627
ENST00000395201
O95661 [Direct mapping]
GTP-binding protein Di-Ras3
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   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 229 aa
25.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.