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NFIA

GENERAL INFORMATION

Gene name

 NFIA

Gene description

 Nuclear factor I/A

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 13
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (AN3-CA)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA006111 , HPA008884
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable), renal cancer (favourable) and head and neck cancer (favourable).
Urothelial cancer p<0.001
Renal cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA006111
HPA008884

GENE INFORMATION

Gene name

 NFIA (HGNC Symbol)

Synonyms

 KIAA1439, NFI-L

Description

 Nuclear factor I/A (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the NF1 (nuclear factor 1) family of transcription factors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Chromosome

 1

Cytoband

 p31.3

Chromosome location (bp)

 60865259 - 61462793

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162599 (version 83.38)

Entrez gene

 4774

UniProt

 Q12857 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12857

Antibodypedia

 NFIA antibodies

PROTEIN BROWSER
«
NFIA-001
NFIA-002
NFIA-003
NFIA-005
NFIA-006
NFIA-007
NFIA-008
NFIA-010
NFIA-011
NFIA-012
NFIA-013
NFIA-014
NFIA-015
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NFIA-001
ENSP00000384523
ENST00000403491
Q12857 [Direct mapping]
Nuclear factor 1 A-type
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Predicted intracellular proteins
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0008134 [transcription factor binding]
GO:0019079 [viral genome replication]
GO:0030054 [cell junction]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
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 509 aa
55.9 kDa 		No 0
NFIA-002
ENSP00000360233
ENST00000371191
B1AKN8 [Direct mapping]
Nuclear factor 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030054 [cell junction]
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 532 aa
58.5 kDa 		No 0
NFIA-003
ENSP00000360229
ENST00000371187
Q12857 [Direct mapping]
Nuclear factor 1 A-type
Show all
Predicted intracellular proteins
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0008134 [transcription factor binding]
GO:0019079 [viral genome replication]
GO:0030054 [cell junction]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 498 aa
54.6 kDa 		No 0
NFIA-005
ENSP00000360227
ENST00000371185
B1AKN5 [Direct mapping]
Nuclear factor 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030054 [cell junction]
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 487 aa
53.6 kDa 		No 0
NFIA-006
ENSP00000360226
ENST00000371184
B1AKN6 [Direct mapping]
Nuclear factor 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 380 aa
42.3 kDa 		No 0
NFIA-007
ENSP00000419785
ENST00000485903
B1AKN7 [Direct mapping]
Nuclear factor 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 466 aa
51.5 kDa 		No 0
NFIA-008
ENSP00000474462
ENST00000357977
S4R3K5 [Direct mapping]
Nuclear factor 1 A-type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 157 aa
16.7 kDa 		No 0
NFIA-010
ENSP00000474806
ENST00000482020
S4R3W2 [Direct mapping]
Nuclear factor 1 A-type
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 184 aa
19.7 kDa 		No 0
NFIA-011
ENSP00000474817
ENST00000493627
S4R3W6 [Direct mapping]
Nuclear factor 1 A-type
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 47 aa
5 kDa 		No 0
NFIA-012
ENSP00000473830
ENST00000496712
S4R308 [Direct mapping]
Nuclear factor 1 A-type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 95 aa
10.4 kDa 		No 0
NFIA-013
ENSP00000474461
ENST00000476646
S4R3K4 [Direct mapping]
Nuclear factor 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 186 aa
21 kDa 		No 0
NFIA-014
ENSP00000384680
ENST00000407417
Q12857 [Direct mapping]
Nuclear factor 1 A-type
Show all
Predicted intracellular proteins
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0008134 [transcription factor binding]
GO:0019079 [viral genome replication]
GO:0030054 [cell junction]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 501 aa
55 kDa 		No 0
NFIA-015
ENSP00000360231
ENST00000371189
Q12857 [Direct mapping]
Nuclear factor 1 A-type
Show all
Predicted intracellular proteins
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0008134 [transcription factor binding]
GO:0019079 [viral genome replication]
GO:0030054 [cell junction]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060074 [synapse maturation]
Show all
 554 aa
60.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.