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MYSM1

GENERAL INFORMATION

Gene name

 MYSM1

Gene description

 Myb-like, SWIRM and MPN domains 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression with additional cytoplasm.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA054291
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable).
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA054291

GENE INFORMATION

Gene name

 MYSM1 (HGNC Symbol)

Synonyms

 KIAA1915

Description

 Myb-like, SWIRM and MPN domains 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 p32.1

Chromosome location (bp)

 58654739 - 58700092

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162601 (version 83.38)

Entrez gene

 114803

UniProt

 Q5VVJ2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5VVJ2

Antibodypedia

 MYSM1 antibodies

PROTEIN BROWSER
MYSM1-001
MYSM1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYSM1-001
ENSP00000418734
ENST00000472487
Q5VVJ2 [Direct mapping]
Histone H2A deubiquitinase MYSM1
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Enzymes
   Peptidases
   Metallopeptidases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0008237 [metallopeptidase activity]
GO:0015630 [microtubule cytoskeleton]
GO:0030334 [regulation of cell migration]
GO:0032403 [protein complex binding]
GO:0035522 [monoubiquitinated histone H2A deubiquitination]
GO:0042393 [histone binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051797 [regulation of hair follicle development]
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 828 aa
95 kDa 		No 0
MYSM1-201
ENSP00000478391
ENST00000622766
Q5VVJ2 [Direct mapping]
Histone H2A deubiquitinase MYSM1
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Enzymes
   Peptidases
   Metallopeptidases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0008237 [metallopeptidase activity]
GO:0015630 [microtubule cytoskeleton]
GO:0032403 [protein complex binding]
GO:0035522 [monoubiquitinated histone H2A deubiquitination]
GO:0042393 [histone binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
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 234 aa
26.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.