Tissue expression of LHX8 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	LHX8
Gene description	LIM homeobox 8
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (placenta, testis, tonsil)
GTEx:	Tissue enhanced (caudate, salivary gland)
FANTOM5:	Group enriched (caudate, tonsil)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (placenta, testis, tonsil)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (caudate, salivary gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (caudate, tonsil)

GENE INFORMATION
Gene name	LHX8 (HGNC Symbol)
Synonyms	Lhx7
Description	LIM homeobox 8 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Chromosome	1
Cytoband	p31.1
Chromosome location (bp)	75128434 - 75161533
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162624 (version 83.38)
Entrez gene	431707
UniProt	Q68G74 (UniProt - Evidence at protein level)
neXtProt	NX_Q68G74
Antibodypedia	LHX8 antibodies

PROTEIN BROWSER

LHX8-001	LHX8-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LHX8-001 ENSP00000294638 ENST00000294638	Q68G74 [Direct mapping] LIM/homeobox protein Lhx8 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0001674 [female germ cell nucleus] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007611 [learning or memory] GO:0008270 [zinc ion binding] GO:0008585 [female gonad development] GO:0021879 [forebrain neuron differentiation] GO:0021884 [forebrain neuron development] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0043565 [sequence-specific DNA binding] Show all	356 aa 39.3 kDa	No	0
LHX8-002 ENSP00000348597 ENST00000356261	Q68G74 [Direct mapping] LIM/homeobox protein Lhx8 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043565 [sequence-specific DNA binding] Show all	346 aa 38.2 kDa	No	0