Expression of NTNG1 in cancer - Summary - The Human Protein Atlas

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NTNG1

TISSUE

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CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	NTNG1
Gene description	Netrin G1
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (ASC TERT1, RPTEC TERT1, U-138 MG, U-87 MG)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	NTNG1 (HGNC Symbol)
Synonyms	KIAA0976, Lmnt1
Description	Netrin G1 (HGNC Symbol)
Entrez gene summary	This gene encodes a preproprotein that is processed into a secreted protein containing eukaroytic growth factor (EGF)-like domains. This protein acts to guide axon growth during neuronal development. Polymorphisms in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2015]
Chromosome	1
Cytoband	p13.3
Chromosome location (bp)	107140007 - 107483458
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162631 (version 83.38)
Entrez gene	22854
UniProt	Q9Y2I2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2I2
Antibodypedia	NTNG1 antibodies

PROTEIN BROWSER

NTNG1-001	NTNG1-004	NTNG1-005	NTNG1-006	NTNG1-007	NTNG1-201	NTNG1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NTNG1-001 ENSP00000359091 ENST00000370074	Q9Y2I2 [Direct mapping] Netrin-G1 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0007409 [axonogenesis] GO:0046658 [anchored component of plasma membrane] Show all	438 aa 49.3 kDa	Yes	0
NTNG1-004 ENSP00000359084 ENST00000370067	Q9Y2I2 [Direct mapping] Netrin-G1 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0007409 [axonogenesis] GO:0046658 [anchored component of plasma membrane] Show all	460 aa 51.9 kDa	Yes	0
NTNG1-005 ENSP00000359083 ENST00000370066	Q9Y2I2 [Direct mapping] Netrin-G1 X5DNW2 [Target identity:100%; Query identity:100%] Netrin G1 isoform A Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0007409 [axonogenesis] GO:0046658 [anchored component of plasma membrane] Show all	480 aa 53.9 kDa	Yes	0
NTNG1-006 ENSP00000359085 ENST00000370068	Q9Y2I2 [Direct mapping] Netrin-G1 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007409 [axonogenesis] GO:0046658 [anchored component of plasma membrane] Show all	539 aa 60.5 kDa	Yes	0
NTNG1-007 ENSP00000359082 ENST00000370065	Q9Y2I2 [Direct mapping] Netrin-G1 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0007409 [axonogenesis] GO:0046658 [anchored component of plasma membrane] Show all	494 aa 55.7 kDa	Yes	0
NTNG1-201 ENSP00000359088 ENST00000370071	Q9Y2I2 [Direct mapping] Netrin-G1 X5DNW2 [Target identity:100%; Query identity:100%] Netrin G1 isoform A Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0007409 [axonogenesis] GO:0046658 [anchored component of plasma membrane] Show all	480 aa 53.9 kDa	Yes	0
NTNG1-202 ENSP00000359090 ENST00000370073	Q9Y2I2 [Direct mapping] Netrin-G1 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0007409 [axonogenesis] GO:0046658 [anchored component of plasma membrane] Show all	539 aa 60.5 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.