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GBP2

GENERAL INFORMATION

Gene name

 GBP2

Gene description

 Guanylate binding protein 2, interferon-inducible

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (EFO-21, HDLM-2, RT4)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA042682 , CAB045975
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), urothelial cancer (favourable), pancreatic cancer (unfavourable) and breast cancer (favourable).
Renal cancer p<0.001
Urothelial cancer p<0.001
Pancreatic cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042682
CAB045975

GENE INFORMATION

Gene name

 GBP2

Synonyms

Description

 Guanylate binding protein 2, interferon-inducible (HGNC Symbol)

Entrez gene summary

 This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may play a role as a marker of squamous cell carcinomas. [provided by RefSeq, Jul 2013]

Chromosome

 1

Cytoband

 p22.2

Chromosome location (bp)

 89106132 - 89150456

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162645 (version 83.38)

Entrez gene

 2634

UniProt

 P32456 (UniProt - Evidence at protein level)

neXtProt

 NX_P32456

Antibodypedia

 GBP2 antibodies

PROTEIN BROWSER
GBP2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GBP2-002
ENSP00000359497
ENST00000370466
P32456 [Direct mapping]
Guanylate-binding protein 2
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   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005829 [cytosol]
GO:0006955 [immune response]
GO:0008152 [metabolic process]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
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 591 aa
67.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.