Expression of KCNT2 in cancer - Summary - The Human Protein Atlas

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KCNT2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KCNT2
Gene description	Potassium channel, sodium activated subfamily T, member 2
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Intracellular,Membrane
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (NTERA-2, SCLC-21H, SH-SY5Y)
HPA (normal tissue):	Tissue enhanced (ovary)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA051218
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051218

GENE INFORMATION
Gene name	KCNT2 (HGNC Symbol)
Synonyms	KCa4.2, SLICK, SLO2.1
Description	Potassium channel, sodium activated subfamily T, member 2 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q31.3
Chromosome location (bp)	196225779 - 196609225
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162687 (version 83.38)
Entrez gene	343450
UniProt	Q6UVM3 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UVM3
Antibodypedia	KCNT2 antibodies

PROTEIN BROWSER

KCNT2-001	KCNT2-002	KCNT2-006	KCNT2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNT2-001 ENSP00000294725 ENST00000294725	Q6UVM3 [Direct mapping] Potassium channel subfamily T member 2 A9LNM6 [Target identity:100%; Query identity:100%] Sodium activated potassium channel Show all	Transporters Transporter channels and pores Voltage-gated ion channels Calcium-Activated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005249 [voltage-gated potassium channel activity] GO:0005524 [ATP binding] GO:0006813 [potassium ion transport] GO:0008076 [voltage-gated potassium channel complex] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0071805 [potassium ion transmembrane transport] Show all	1135 aa 130.5 kDa	No	6
KCNT2-002 ENSP00000356403 ENST00000367433	Q6UVM3 [Direct mapping] Potassium channel subfamily T member 2 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Calcium-Activated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005249 [voltage-gated potassium channel activity] GO:0005524 [ATP binding] GO:0006813 [potassium ion transport] GO:0008076 [voltage-gated potassium channel complex] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0071805 [potassium ion transmembrane transport] Show all	1111 aa 127.7 kDa	No	6
KCNT2-006 ENSP00000476657 ENST00000609185	Q6UVM3 [Direct mapping] Potassium channel subfamily T member 2 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Calcium-Activated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005249 [voltage-gated potassium channel activity] GO:0005524 [ATP binding] GO:0006813 [potassium ion transport] GO:0008076 [voltage-gated potassium channel complex] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0071805 [potassium ion transmembrane transport] Show all	1068 aa 122.6 kDa	No	6
KCNT2-201 ENSP00000405474 ENST00000451324	Q3SY61 [Direct mapping] KCNT2 protein; Potassium channel subfamily T member 2 Show all	Predicted intracellular proteins Show all	GO:0005249 [voltage-gated potassium channel activity] GO:0006813 [potassium ion transport] GO:0008076 [voltage-gated potassium channel complex] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0071805 [potassium ion transmembrane transport] Show all	370 aa 41.9 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.