Cell atlas - AGL - The Human Protein Atlas

GENERAL INFORMATION
Gene name	AGL
Gene description	Amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA028498 , HPA054340
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (supported)

Additional location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA028498	A-431	Nucleoplasm
HPA028498	A-431	Cytosol
HPA028498	U-2 OS	Nucleoplasm
		Nuclear bodies
		Cytosol
HPA028498	U-251 MG	Nucleoplasm
HPA028498	U-251 MG	Cytosol
HPA054340	A-431	Nucleoplasm
HPA054340	Hep G2	Nucleoplasm
HPA054340	U-2 OS	Nucleoplasm

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000033400 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA054340	NIH 3T3	No staining

GENE INFORMATION
Gene name	AGL
Synonyms
Description	Amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase (HGNC Symbol)
Entrez gene summary	This gene encodes the glycogen debrancher enzyme which is involved in glycogen degradation. This enzyme has two independent catalytic activities which occur at different sites on the protein: a 4-alpha-glucotransferase activity and a amylo-1,6-glucosidase activity. Mutations in this gene are associated with glycogen storage disease although a wide range of enzymatic and clinical variability occurs which may be due to tissue-specific alternative splicing. Alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p21.2
Chromosome location (bp)	99850084 - 99924023
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162688 (version 83.38)
Entrez gene	178
UniProt	P35573 (UniProt - Evidence at protein level)
neXtProt	NX_P35573
Antibodypedia	AGL antibodies

PROTEIN BROWSER

AGL-001	AGL-002	AGL-003	AGL-004	AGL-005	AGL-006	AGL-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AGL-001 ENSP00000355106 ENST00000361915	P35573 [Direct mapping] Glycogen debranching enzyme 4-alpha-glucanotransferase Amylo-alpha-1,6-glucosidase Show all	Enzymes ENZYME proteins Transferases Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004133 [glycogen debranching enzyme activity] GO:0004134 [4-alpha-glucanotransferase activity] GO:0004135 [amylo-alpha-1,6-glucosidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0005978 [glycogen biosynthetic process] GO:0005980 [glycogen catabolic process] GO:0006006 [glucose metabolic process] GO:0043033 [isoamylase complex] GO:0044281 [small molecule metabolic process] Show all	1532 aa 174.8 kDa	No	1
AGL-002 ENSP00000359184 ENST00000370165	P35573 [Direct mapping] Glycogen debranching enzyme 4-alpha-glucanotransferase Amylo-alpha-1,6-glucosidase Show all	Enzymes ENZYME proteins Transferases Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004133 [glycogen debranching enzyme activity] GO:0004134 [4-alpha-glucanotransferase activity] GO:0004135 [amylo-alpha-1,6-glucosidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0005978 [glycogen biosynthetic process] GO:0005980 [glycogen catabolic process] GO:0006006 [glucose metabolic process] GO:0043033 [isoamylase complex] GO:0044281 [small molecule metabolic process] Show all	1532 aa 174.8 kDa	No	1
AGL-003 ENSP00000359182 ENST00000370163	P35573 [Direct mapping] Glycogen debranching enzyme 4-alpha-glucanotransferase Amylo-alpha-1,6-glucosidase Show all	Enzymes ENZYME proteins Transferases Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004133 [glycogen debranching enzyme activity] GO:0004134 [4-alpha-glucanotransferase activity] GO:0004135 [amylo-alpha-1,6-glucosidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0005978 [glycogen biosynthetic process] GO:0005980 [glycogen catabolic process] GO:0006006 [glucose metabolic process] GO:0043033 [isoamylase complex] GO:0044281 [small molecule metabolic process] Show all	1532 aa 174.8 kDa	No	1
AGL-004 ENSP00000294724 ENST00000294724	P35573 [Direct mapping] Glycogen debranching enzyme 4-alpha-glucanotransferase Amylo-alpha-1,6-glucosidase Show all	Enzymes ENZYME proteins Transferases Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004133 [glycogen debranching enzyme activity] GO:0004134 [4-alpha-glucanotransferase activity] GO:0004135 [amylo-alpha-1,6-glucosidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0005977 [glycogen metabolic process] GO:0005978 [glycogen biosynthetic process] GO:0005980 [glycogen catabolic process] GO:0006006 [glucose metabolic process] GO:0007584 [response to nutrient] GO:0009725 [response to hormone] GO:0016234 [inclusion body] GO:0016529 [sarcoplasmic reticulum] GO:0030246 [carbohydrate binding] GO:0030247 [polysaccharide binding] GO:0031593 [polyubiquitin binding] GO:0043033 [isoamylase complex] GO:0044281 [small molecule metabolic process] GO:0051384 [response to glucocorticoid] Show all	1532 aa 174.8 kDa	No	1
AGL-005 ENSP00000354971 ENST00000361302	P35573 [Direct mapping] Glycogen debranching enzyme 4-alpha-glucanotransferase Amylo-alpha-1,6-glucosidase Show all	Enzymes ENZYME proteins Transferases Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004133 [glycogen debranching enzyme activity] GO:0004134 [4-alpha-glucanotransferase activity] GO:0004135 [amylo-alpha-1,6-glucosidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0005978 [glycogen biosynthetic process] GO:0005980 [glycogen catabolic process] GO:0006006 [glucose metabolic process] GO:0043033 [isoamylase complex] GO:0044281 [small molecule metabolic process] Show all	1516 aa 172.7 kDa	No	1
AGL-006 ENSP00000354635 ENST00000361522	P35573 [Direct mapping] Glycogen debranching enzyme 4-alpha-glucanotransferase Amylo-alpha-1,6-glucosidase Show all	Enzymes ENZYME proteins Transferases Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004133 [glycogen debranching enzyme activity] GO:0004134 [4-alpha-glucanotransferase activity] GO:0004135 [amylo-alpha-1,6-glucosidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0005978 [glycogen biosynthetic process] GO:0005980 [glycogen catabolic process] GO:0006006 [glucose metabolic process] GO:0043033 [isoamylase complex] GO:0044281 [small molecule metabolic process] Show all	1515 aa 172.6 kDa	No	1
AGL-201 ENSP00000359180 ENST00000370161	P35573 [Direct mapping] Glycogen debranching enzyme 4-alpha-glucanotransferase Amylo-alpha-1,6-glucosidase Show all	Enzymes ENZYME proteins Transferases Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004133 [glycogen debranching enzyme activity] GO:0004134 [4-alpha-glucanotransferase activity] GO:0004135 [amylo-alpha-1,6-glucosidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0005978 [glycogen biosynthetic process] GO:0005980 [glycogen catabolic process] GO:0006006 [glucose metabolic process] GO:0043033 [isoamylase complex] GO:0044281 [small molecule metabolic process] Show all	1516 aa 172.7 kDa	No	1