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ARPC5

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GENERAL INFORMATION

Gene name

 ARPC5

Gene description

 Actin related protein 2/3 complex, subunit 5, 16kDa

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane, cytosol, cell junctions & vesicles.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (approved), Plasma membrane (approved), Cell Junctions (approved), Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA031972
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane, cytosol, cell junctions & vesicles.

Main location

 Vesicles (approved), Plasma membrane (approved), Cell Junctions (approved), Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA031972 A-431 Vesicles
Plasma membrane
Cell Junctions
HPA031972 U-2 OS Vesicles
Cytosol
HPA031972 U-251 MG Vesicles
Cytosol

GENE INFORMATION

Gene name

 ARPC5 (HGNC Symbol)

Synonyms

 ARC16, dJ127C7.3, p16-Arc

Description

 Actin related protein 2/3 complex, subunit 5, 16kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 subunit, has yet to be determined. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Chromosome

 1

Cytoband

 q25.3

Chromosome location (bp)

 183620846 - 183635757

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162704 (version 83.38)

Entrez gene

 10092

UniProt

 O15511 (UniProt - Evidence at protein level)

neXtProt

 NX_O15511

Antibodypedia

 ARPC5 antibodies

PROTEIN BROWSER
ARPC5-001
ARPC5-002
ARPC5-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARPC5-001
ENSP00000352918
ENST00000359856
O15511 [Direct mapping]
Actin-related protein 2/3 complex subunit 5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005885 [Arp2/3 protein complex]
GO:0005925 [focal adhesion]
GO:0006928 [movement of cell or subcellular component]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0030036 [actin cytoskeleton organization]
GO:0030833 [regulation of actin filament polymerization]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042995 [cell projection]
GO:0045087 [innate immune response]
GO:0048013 [ephrin receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
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 151 aa
16.3 kDa 		No 0
ARPC5-002
ENSP00000294742
ENST00000294742
O15511 [Direct mapping]
Actin-related protein 2/3 complex subunit 5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005885 [Arp2/3 protein complex]
GO:0005925 [focal adhesion]
GO:0006928 [movement of cell or subcellular component]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0030036 [actin cytoskeleton organization]
GO:0030833 [regulation of actin filament polymerization]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042995 [cell projection]
GO:0045087 [innate immune response]
GO:0048013 [ephrin receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
Show all
 154 aa
16.6 kDa 		No 0
ARPC5-004
ENSP00000356504
ENST00000367534
B1ALC0 [Direct mapping]
Actin-related protein 2/3 complex subunit 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005885 [Arp2/3 protein complex]
GO:0015629 [actin cytoskeleton]
GO:0030833 [regulation of actin filament polymerization]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
Show all
 135 aa
14.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.