Cell atlas - DDR2 - The Human Protein Atlas

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DDR2

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Actin filaments
	Plasma membrane

Human cell
	Actin Filaments
	Plasma Membrane

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GENERAL INFORMATION
Gene name	DDR2
Gene description	Discoidin domain receptor tyrosine kinase 2
Protein class	CD markers Disease related genes Enzymes FDA approved drug targets Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane & actin filaments.
RNA cell category	Cell line enhanced (ASC TERT1, BJ hTERT+)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (supported), Actin filaments (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA070112
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (ASC TERT1, BJ hTERT+) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane & actin filaments.

Main location

Plasma membrane (supported), Actin filaments (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA070112	BJ	Actin filaments	Intensity
	HPA070112	U-2 OS	Plasma membrane	Intensity
	HPA070112	U-2 OS	Actin filaments	Intensity

GENE INFORMATION
Gene name	DDR2 (HGNC Symbol)
Synonyms	NTRKR3, TKT, TYRO10
Description	Discoidin domain receptor tyrosine kinase 2 (HGNC Symbol)
Entrez gene summary	Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q23.3
Chromosome location (bp)	162631373 - 162787400
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162733 (version 83.38)
Entrez gene	4921
UniProt	Q16832 (UniProt - Evidence at protein level)
neXtProt	NX_Q16832
Antibodypedia	DDR2 antibodies

PROTEIN BROWSER

DDR2-001	DDR2-002	DDR2-003	DDR2-004	DDR2-005	DDR2-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DDR2-001 ENSP00000356899 ENST00000367922	Q16832 [Direct mapping] Discoidin domain-containing receptor 2 A0A024R906 [Target identity:100%; Query identity:100%] Discoidin domain receptor family, member 2, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001503 [ossification] GO:0003416 [endochondral bone growth] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0006468 [protein phosphorylation] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0010715 [regulation of extracellular matrix disassembly] GO:0010763 [positive regulation of fibroblast migration] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030198 [extracellular matrix organization] GO:0030199 [collagen fibril organization] GO:0030500 [regulation of bone mineralization] GO:0031214 [biomineral tissue development] GO:0035988 [chondrocyte proliferation] GO:0038062 [protein tyrosine kinase collagen receptor activity] GO:0038063 [collagen-activated tyrosine kinase receptor signaling pathway] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045860 [positive regulation of protein kinase activity] GO:0046777 [protein autophosphorylation] GO:0048146 [positive regulation of fibroblast proliferation] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0070062 [extracellular exosome] GO:0090091 [positive regulation of extracellular matrix disassembly] Show all	855 aa 96.7 kDa	Yes	1
DDR2-002 ENSP00000356898 ENST00000367921	Q16832 [Direct mapping] Discoidin domain-containing receptor 2 A0A024R906 [Target identity:100%; Query identity:100%] Discoidin domain receptor family, member 2, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001503 [ossification] GO:0003416 [endochondral bone growth] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0006468 [protein phosphorylation] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0010715 [regulation of extracellular matrix disassembly] GO:0010763 [positive regulation of fibroblast migration] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030198 [extracellular matrix organization] GO:0030199 [collagen fibril organization] GO:0030500 [regulation of bone mineralization] GO:0031214 [biomineral tissue development] GO:0035988 [chondrocyte proliferation] GO:0038062 [protein tyrosine kinase collagen receptor activity] GO:0038063 [collagen-activated tyrosine kinase receptor signaling pathway] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045860 [positive regulation of protein kinase activity] GO:0046777 [protein autophosphorylation] GO:0048146 [positive regulation of fibroblast proliferation] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0070062 [extracellular exosome] GO:0090091 [positive regulation of extracellular matrix disassembly] Show all	855 aa 96.7 kDa	Yes	1
DDR2-003 ENSP00000391310 ENST00000415555	Q5T244 [Direct mapping] Discoidin domain-containing receptor 2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		148 aa 16.5 kDa	Yes	0
DDR2-004 ENSP00000400309 ENST00000446985	Q5T245 [Direct mapping] Discoidin domain-containing receptor 2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		130 aa 14.4 kDa	Yes	0
DDR2-005 ENSP00000417030 ENST00000458105	Q5T241 [Direct mapping] Discoidin domain-containing receptor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	166 aa 18.7 kDa	No	1
DDR2-006 ENSP00000396864 ENST00000433757	H0Y570 [Direct mapping] Discoidin domain-containing receptor 2 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		171 aa 18.9 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.