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Gene name

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Chromosome

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Reliability

Reliability

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Method

Validation

Method

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Cancer

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Detectable

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Antibodies

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VANGL2
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

VANGL2

Gene description

VANGL planar cell polarity protein 2

Protein class

Disease related genes
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (AF22, NTERA-2, SH-SY5Y)
HPA (normal tissue):Tissue enhanced (skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

Uncertain based on 1 antibody.
HPA027043
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all
0.0102030405060708090100FPKMBreast cancer (BRCA)Cervical cancer (CESC)Colorectal cancer (COAD,READ)Endometrial cancer (UCEC)Glioma (GBM)Head and neck cancer (HNSC)Liver cancer (LIHC)Lung cancer (LUAD,LUSC)Melanoma (SKCM)Ovarian cancer (OV)Pancreatic cancer (PAAD)Prostate cancer (PRAD)Renal cancer (KICH,KIRC,KIRP)Stomach cancer (STAD)Testis cancer (TGCT)Thyroid cancer (THCA)Urothelial cancer (BLCA)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY

HPA027043

Cancer

Cancer staining

Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
 

Cancer

Cancer staining

Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary

Most malignancies were generally negative or showed weak cytoplasmic immunoreactivity. Cases of skin and testis cancers showed moderate positivity.

GENE INFORMATION

Gene name

VANGL2 (HGNC Symbol)

Synonyms

KIAA1215, LPP1, LTAP, MGC119403, MGC119404, STB1, STBM, STBM1

Description

VANGL planar cell polarity protein 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011]

Chromosome

1

Cytoband

q23.2

Chromosome location (bp)

160400586 - 160428678

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000162738 (version 83.38)

Entrez gene

57216

UniProt

Q9ULK5 (UniProt - Evidence at protein level)

neXtProt

NX_Q9ULK5

Antibodypedia

VANGL2 antibodies

PROTEIN BROWSER

VANGL2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

VANGL2-001
ENSP00000357040
ENST00000368061
Q9ULK5 [Direct mapping]
Vang-like protein 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0001736 [establishment of planar polarity]
GO:0001843 [neural tube closure]
GO:0001942 [hair follicle development]
GO:0001947 [heart looping]
GO:0003149 [membranous septum morphogenesis]
GO:0003150 [muscular septum morphogenesis]
GO:0003402 [planar cell polarity pathway involved in axis elongation]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0007266 [Rho protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0009952 [anterior/posterior pattern specification]
GO:0015012 [heparan sulfate proteoglycan biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0022007 [convergent extension involved in neural plate elongation]
GO:0030111 [regulation of Wnt signaling pathway]
GO:0030134 [ER to Golgi transport vesicle]
GO:0032835 [glomerulus development]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0035019 [somatic stem cell population maintenance]
GO:0035058 [nonmotile primary cilium assembly]
GO:0035567 [non-canonical Wnt signaling pathway]
GO:0035787 [cell migration involved in kidney development]
GO:0036342 [post-anal tail morphogenesis]
GO:0042060 [wound healing]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0045176 [apical protein localization]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0048103 [somatic stem cell division]
GO:0048105 [establishment of body hair planar orientation]
GO:0048546 [digestive tract morphogenesis]
GO:0060028 [convergent extension involved in axis elongation]
GO:0060029 [convergent extension involved in organogenesis]
GO:0060071 [Wnt signaling pathway, planar cell polarity pathway]
GO:0060119 [inner ear receptor cell development]
GO:0060122 [inner ear receptor stereocilium organization]
GO:0060187 [cell pole]
GO:0060488 [orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis]
GO:0060489 [planar dichotomous subdivision of terminal units involved in lung branching morphogenesis]
GO:0060490 [lateral sprouting involved in lung morphogenesis]
GO:0060993 [kidney morphogenesis]
GO:0061346 [planar cell polarity pathway involved in heart morphogenesis]
GO:0071944 [cell periphery]
GO:0090102 [cochlea development]
GO:0090103 [cochlea morphogenesis]
GO:0090175 [regulation of establishment of planar polarity]
GO:0090177 [establishment of planar polarity involved in neural tube closure]
GO:0090179 [planar cell polarity pathway involved in neural tube closure]
Show all
521 aa
59.7 kDa
No 4

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