Expression of FCGR3B in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

FCGR3B

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	FCGR3B
Gene description	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
Protein class	CD markers FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enhanced (appendix, spleen)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	FCGR3B (HGNC Symbol)
Synonyms	CD16, CD16b, FCG3, FCGR3
Description	Fc fragment of IgG, low affinity IIIb, receptor (CD16b) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012]
Chromosome	1
Cytoband	q23.3
Chromosome location (bp)	161623196 - 161631963
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162747 (version 83.38)
Entrez gene	2215
UniProt	O75015 (UniProt - Evidence at protein level)
neXtProt	NX_O75015
Antibodypedia	FCGR3B antibodies

PROTEIN BROWSER

FCGR3B-001	FCGR3B-002	FCGR3B-003	FCGR3B-005	FCGR3B-201	FCGR3B-202	FCGR3B-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FCGR3B-001 ENSP00000433642 ENST00000531221	M9MML6 [Direct mapping] Low affinity immunoglobulin gamma Fc region receptor III-B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	269 aa 29.9 kDa	No	1
FCGR3B-002 ENSP00000394204 ENST00000421702	H0Y4U3 [Direct mapping] Low affinity immunoglobulin gamma Fc region receptor III-B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	254 aa 28.2 kDa	No	1
FCGR3B-003 ENSP00000356941 ENST00000367964	O75015 [Direct mapping] Low affinity immunoglobulin gamma Fc region receptor III-B Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins FDA approved drug targets Biotech drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0002230 [positive regulation of defense response to virus by host] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0019864 [IgG binding] GO:0031225 [anchored component of membrane] GO:0070062 [extracellular exosome] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	233 aa 26.2 kDa	Yes	1
FCGR3B-005 ENSP00000437084 ENST00000534776	E9PNY5 [Direct mapping] Low affinity immunoglobulin gamma Fc region receptor III-B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	104 aa 11.9 kDa	No	0
FCGR3B-201 ENSP00000294800 ENST00000294800	O75015 [Direct mapping] Low affinity immunoglobulin gamma Fc region receptor III-B Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins FDA approved drug targets Biotech drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0002230 [positive regulation of defense response to virus by host] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0019864 [IgG binding] GO:0031225 [anchored component of membrane] GO:0070062 [extracellular exosome] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	233 aa 26.2 kDa	Yes	1
FCGR3B-202 ENSP00000482838 ENST00000613418	A0A087WZR4 [Direct mapping] Low affinity immunoglobulin gamma Fc region receptor III-B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	216 aa 24.4 kDa	No	1
FCGR3B-203 ENSP00000478466 ENST00000614870	A0A087WU90 [Direct mapping] Low affinity immunoglobulin gamma Fc region receptor III-B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	130 aa 14.4 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.