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This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011]
Predicted intracellular proteins Transcription factors Basic domains Protein evidence (Kim et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006094 [gluconeogenesis] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0008284 [positive regulation of cell proliferation] GO:0010628 [positive regulation of gene expression] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0034198 [cellular response to amino acid starvation] GO:0035914 [skeletal muscle cell differentiation] GO:0036499 [PERK-mediated unfolded protein response] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0061394 [regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance] GO:0070373 [negative regulation of ERK1 and ERK2 cascade] GO:1903984 [positive regulation of TRAIL-activated apoptotic signaling pathway] GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990622 [CHOP-ATF3 complex]
GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0043565 [sequence-specific DNA binding]
Predicted intracellular proteins Transcription factors Basic domains Protein evidence (Kim et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0036499 [PERK-mediated unfolded protein response] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0061394 [regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance] GO:1903984 [positive regulation of TRAIL-activated apoptotic signaling pathway] GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990622 [CHOP-ATF3 complex]
Predicted intracellular proteins Transcription factors Basic domains Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0036499 [PERK-mediated unfolded protein response] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0061394 [regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance] GO:1903984 [positive regulation of TRAIL-activated apoptotic signaling pathway] GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990622 [CHOP-ATF3 complex]
GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0043565 [sequence-specific DNA binding]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0036499 [PERK-mediated unfolded protein response] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0061394 [regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance] GO:1903984 [positive regulation of TRAIL-activated apoptotic signaling pathway] GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990622 [CHOP-ATF3 complex]
Predicted intracellular proteins Transcription factors Basic domains Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0036499 [PERK-mediated unfolded protein response] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0061394 [regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance] GO:1903984 [positive regulation of TRAIL-activated apoptotic signaling pathway] GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990622 [CHOP-ATF3 complex]
Predicted intracellular proteins Transcription factors Basic domains Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0036499 [PERK-mediated unfolded protein response] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0061394 [regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance] GO:1903984 [positive regulation of TRAIL-activated apoptotic signaling pathway] GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990622 [CHOP-ATF3 complex]