Expression of ACP6 in cancer - Summary - The Human Protein Atlas

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ACP6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ACP6
Gene description	Acid phosphatase 6, lysophosphatidic
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (RPTEC TERT1)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA028560
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA028560

GENE INFORMATION
Gene name	ACP6 (HGNC Symbol)
Synonyms	ACPL1, LPAP
Description	Acid phosphatase 6, lysophosphatidic (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q21.2
Chromosome location (bp)	147629652 - 147670496
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162836 (version 83.38)
Entrez gene	51205
UniProt	Q9NPH0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NPH0
Antibodypedia	ACP6 antibodies

PROTEIN BROWSER

ACP6-001	ACP6-002	ACP6-004	ACP6-005	ACP6-006	ACP6-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACP6-001 ENSP00000463574 ENST00000583509	X5D289 [Direct mapping] Acid phosphatase 6, lysophosphatidic; Lysophosphatidic acid phosphatase 6 isoform C; Lysophosphatidic acid phosphatase type 6 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002244 [hematopoietic progenitor cell differentiation] GO:0003993 [acid phosphatase activity] GO:0016311 [dephosphorylation] Show all	428 aa 48.9 kDa	Yes	0
ACP6-002 ENSP00000479906 ENST00000493129	A0A087WW36 [Direct mapping] Lysophosphatidic acid phosphatase type 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003993 [acid phosphatase activity] GO:0016311 [dephosphorylation] Show all	143 aa 16.3 kDa	No	0
ACP6-004 ENSP00000481777 ENST00000487562	Q9NPH0 [Direct mapping] Lysophosphatidic acid phosphatase type 6 X5D319 [Target identity:100%; Query identity:100%] Lysophosphatidic acid phosphatase 6 isoform A Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003993 [acid phosphatase activity] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006644 [phospholipid metabolic process] GO:0016311 [dephosphorylation] GO:0052642 [lysophosphatidic acid phosphatase activity] GO:2001311 [lysobisphosphatidic acid metabolic process] Show all	271 aa 30.8 kDa	Yes	0
ACP6-005 ENSP00000477476 ENST00000609196	V9GZ71 [Direct mapping] Lysophosphatidic acid phosphatase type 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003993 [acid phosphatase activity] Show all	157 aa 17.7 kDa	No	0
ACP6-006 ENSP00000482100 ENST00000611629	A0A087WYU6 [Direct mapping] Lysophosphatidic acid phosphatase type 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003993 [acid phosphatase activity] GO:0016311 [dephosphorylation] Show all	166 aa 18.8 kDa	No	0
ACP6-009 ENSP00000376714 ENST00000392988	A0A0A0MS36 [Direct mapping] Lysophosphatidic acid phosphatase type 6 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003993 [acid phosphatase activity] GO:0016311 [dephosphorylation] Show all	228 aa 25.9 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.