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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ACP6
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ACP6

Gene description

Acid phosphatase 6, lysophosphatidic

Protein class

Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (RPTEC TERT1)
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

Uncertain based on 1 antibody.
HPA028560
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PROGNOSTIC SUMMARY

Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA028560

Cancer

Cancer staining

Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
 

Cancer

Cancer staining

Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary

Hepatocellular carcinomas and prostate cancers displayed moderate cytoplasmic immunoreactivity while occasional cases of endometrial and urothelial cancers exhibited weak to moderate staining. Remaining cancer cells were generally negative.

GENE INFORMATION

Gene name

ACP6 (HGNC Symbol)

Synonyms

ACPL1, LPAP

Description

Acid phosphatase 6, lysophosphatidic (HGNC Symbol)

Entrez gene summary

Chromosome

1

Cytoband

q21.2

Chromosome location (bp)

147629652 - 147670496

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000162836 (version 83.38)

Entrez gene

51205

UniProt

Q9NPH0 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NPH0

Antibodypedia

ACP6 antibodies

PROTEIN BROWSER

ACP6-001
ACP6-002
ACP6-004
ACP6-005
ACP6-006
ACP6-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACP6-001
ENSP00000463574
ENST00000583509
X5D289 [Direct mapping]
Acid phosphatase 6, lysophosphatidic; Lysophosphatidic acid phosphatase 6 isoform C; Lysophosphatidic acid phosphatase type 6
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002244 [hematopoietic progenitor cell differentiation]
GO:0003993 [acid phosphatase activity]
GO:0016311 [dephosphorylation]
Show all
428 aa
48.9 kDa
Yes 0
ACP6-002
ENSP00000479906
ENST00000493129
A0A087WW36 [Direct mapping]
Lysophosphatidic acid phosphatase type 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003993 [acid phosphatase activity]
GO:0016311 [dephosphorylation]
Show all
143 aa
16.3 kDa
No 0
ACP6-004
ENSP00000481777
ENST00000487562
Q9NPH0 [Direct mapping]
Lysophosphatidic acid phosphatase type 6
X5D319 [Target identity:100%; Query identity:100%]
Lysophosphatidic acid phosphatase 6 isoform A
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003993 [acid phosphatase activity]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006644 [phospholipid metabolic process]
GO:0016311 [dephosphorylation]
GO:0052642 [lysophosphatidic acid phosphatase activity]
GO:2001311 [lysobisphosphatidic acid metabolic process]
Show all
271 aa
30.8 kDa
Yes 0
ACP6-005
ENSP00000477476
ENST00000609196
V9GZ71 [Direct mapping]
Lysophosphatidic acid phosphatase type 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003993 [acid phosphatase activity]
Show all
157 aa
17.7 kDa
No 0
ACP6-006
ENSP00000482100
ENST00000611629
A0A087WYU6 [Direct mapping]
Lysophosphatidic acid phosphatase type 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003993 [acid phosphatase activity]
GO:0016311 [dephosphorylation]
Show all
166 aa
18.8 kDa
No 0
ACP6-009
ENSP00000376714
ENST00000392988
A0A0A0MS36 [Direct mapping]
Lysophosphatidic acid phosphatase type 6
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003993 [acid phosphatase activity]
GO:0016311 [dephosphorylation]
Show all
228 aa
25.9 kDa
Yes 0

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