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CNST

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GENERAL INFORMATION

Gene name

 CNST

Gene description

 Consortin, connexin sorting protein

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to vesicles.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA007226
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to vesicles.

Main location

 Vesicles (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA007226 BJ Vesicles
HPA007226 U-2 OS Vesicles

GENE INFORMATION

Gene name

 CNST (HGNC Symbol)

Synonyms

 C1orf71, FLJ32001, PPP1R64

Description

 Consortin, connexin sorting protein (HGNC Symbol)

Entrez gene summary

 Targeting of numerous transmembrane proteins to the cell surface is thought to depend on their recognition by cargo receptors that interact with the adaptor machinery for anterograde traffic at the distal end of the Golgi complex. Consortin (CNST) is an integral membrane protein that acts as a binding partner of connexins, the building blocks of gap junctions, and acts as a trans-Golgi network (TGN) receptor involved in connexin targeting to the plasma membrane and recycling from the cell surface (del Castillo et al., 2010 [PubMed 19864490]).[supplied by OMIM, Jun 2010]

Chromosome

 1

Cytoband

 q44

Chromosome location (bp)

 246566444 - 246668584

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162852 (version 83.38)

Entrez gene

 163882

UniProt

 Q6PJW8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6PJW8

Antibodypedia

 CNST antibodies

PROTEIN BROWSER
CNST-001
CNST-002
CNST-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CNST-001
ENSP00000355470
ENST00000366513
Q6PJW8 [Direct mapping]
Consortin
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005802 [trans-Golgi network]
GO:0005886 [plasma membrane]
GO:0010923 [negative regulation of phosphatase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019902 [phosphatase binding]
GO:0030133 [transport vesicle]
GO:0042998 [positive regulation of Golgi to plasma membrane protein transport]
GO:0043234 [protein complex]
GO:0071253 [connexin binding]
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 725 aa
79.6 kDa 		No 1
CNST-002
ENSP00000355469
ENST00000366512
Q6PJW8 [Direct mapping]
Consortin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005802 [trans-Golgi network]
GO:0005886 [plasma membrane]
GO:0010923 [negative regulation of phosphatase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019902 [phosphatase binding]
GO:0030133 [transport vesicle]
GO:0042998 [positive regulation of Golgi to plasma membrane protein transport]
GO:0043234 [protein complex]
GO:0071253 [connexin binding]
Show all
 616 aa
67.5 kDa 		No 0
CNST-004
ENSP00000355468
ENST00000366511
B1AQM9 [Direct mapping]
Consortin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 137 aa
14.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.