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KLHDC8A

GENERAL INFORMATION

Gene name

 KLHDC8A

Gene description

 Kelch domain containing 8A

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (ovary)
GTEx:Tissue enriched (ovary)
FANTOM5:Tissue enhanced (ovary)

Protein evidence

 Evidence at transcript level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (ovary)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (ovary)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (ovary)

GENE INFORMATION

Gene name

 KLHDC8A (HGNC Symbol)

Synonyms

 FLJ10748

Description

 Kelch domain containing 8A (HGNC Symbol)

Entrez gene summary

 This gene encodes a kelch domain-containing protein which is upregulated in cancer. Upregulated expression of the encoded protein may provide an alternative pathway for tumors to maintain aggressiveness in the absence of epidermal growth factor receptor dependence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Chromosome

 1

Cytoband

 q32.1

Chromosome location (bp)

 205336065 - 205357090

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000162873 (version 83.38)

Entrez gene

 55220

UniProt

 Q8IYD2 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8IYD2

Antibodypedia

 KLHDC8A antibodies

PROTEIN BROWSER
KLHDC8A-001
KLHDC8A-002
KLHDC8A-003
KLHDC8A-004
KLHDC8A-005
KLHDC8A-007
KLHDC8A-008
KLHDC8A-009
KLHDC8A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KLHDC8A-001
ENSP00000356123
ENST00000367155
Q8IYD2 [Direct mapping]
Kelch domain-containing protein 8A
A0A024R981 [Target identity:100%; Query identity:100%]
Kelch domain containing 8A, isoform CRA_a
Show all
Predicted intracellular proteins
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
Show all
 350 aa
38.9 kDa 		No 0
KLHDC8A-002
ENSP00000356124
ENST00000367156
Q8IYD2 [Direct mapping]
Kelch domain-containing protein 8A
A0A024R981 [Target identity:100%; Query identity:100%]
Kelch domain containing 8A, isoform CRA_a
Show all
Predicted intracellular proteins
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
Show all
 350 aa
38.9 kDa 		No 0
KLHDC8A-003
ENSP00000475334
ENST00000491471
U3KPX9 [Direct mapping]
Kelch domain-containing protein 8A
Show all
Predicted intracellular proteins
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
Show all
 66 aa
7.4 kDa 		No 0
KLHDC8A-004
ENSP00000475871
ENST00000460687
U3KQH1 [Direct mapping]
Kelch domain-containing protein 8A
Show all
Predicted intracellular proteins
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
Show all
 216 aa
24.2 kDa 		No 0
KLHDC8A-005
ENSP00000475955
ENST00000606887
U3KQK4 [Direct mapping]
Kelch domain-containing protein 8A
Show all
Predicted intracellular proteins
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
Show all
 26 aa
3.1 kDa 		No 0
KLHDC8A-007
ENSP00000475902
ENST00000607826
U3KQI4 [Direct mapping]
Kelch domain-containing protein 8A
Show all
Predicted intracellular proteins
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
Show all
 83 aa
9.2 kDa 		No 0
KLHDC8A-008
ENSP00000475290
ENST00000607173
U3KPW1 [Direct mapping]
Kelch domain-containing protein 8A
Show all
Predicted intracellular proteins
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
Show all
 79 aa
8.6 kDa 		No 0
KLHDC8A-009
ENSP00000475745
ENST00000606181
U3KQC2 [Direct mapping]
Kelch domain-containing protein 8A
Show all
Predicted intracellular proteins
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
Show all
 176 aa
20.2 kDa 		No 0
KLHDC8A-201
ENSP00000442229
ENST00000539253
Q8IYD2 [Direct mapping]
Kelch domain-containing protein 8A
A0A024R981 [Target identity:100%; Query identity:100%]
Kelch domain containing 8A, isoform CRA_a
Show all
Predicted intracellular proteins
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
Show all
 350 aa
38.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.