Expression of IL24 in cancer - Summary - The Human Protein Atlas

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IL24

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	IL24
Gene description	Interleukin 24
Protein class	Cancer-related genes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enriched (BJ hTERT+)
HPA (normal tissue):	Group enriched (appendix, lymph node, spleen, tonsil)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression in several different tissue types.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. CAB025972
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable).
Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB025972

GENE INFORMATION
Gene name	IL24 (HGNC Symbol)
Synonyms	C49A, FISP, IL-24, IL10B, mda-7, Mob-5, ST16
Description	Interleukin 24 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q32.1
Chromosome location (bp)	206897443 - 206904139
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162892 (version 83.38)
Entrez gene	11009
UniProt	Q13007 (UniProt - Evidence at protein level)
neXtProt	NX_Q13007
Antibodypedia	IL24 antibodies

PROTEIN BROWSER

IL24-001	IL24-002	IL24-005	IL24-006	IL24-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IL24-001 ENSP00000294984 ENST00000294984	Q13007 [Direct mapping] Interleukin-24 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0005125 [cytokine activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0046427 [positive regulation of JAK-STAT cascade] Show all	206 aa 23.8 kDa	Yes	0
IL24-002 ENSP00000375795 ENST00000391929	Q13007 [Direct mapping] Interleukin-24 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0005125 [cytokine activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0030336 [negative regulation of cell migration] GO:0033136 [serine phosphorylation of STAT3 protein] GO:0042060 [wound healing] GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein] GO:0046427 [positive regulation of JAK-STAT cascade] GO:0071222 [cellular response to lipopolysaccharide] GO:0071353 [cellular response to interleukin-4] Show all	207 aa 23.9 kDa	Yes	0
IL24-005 ENSP00000356060 ENST00000367093	Q13007 [Direct mapping] Interleukin-24 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0005125 [cytokine activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0046427 [positive regulation of JAK-STAT cascade] Show all	154 aa 17.8 kDa	Yes	0
IL24-006 ENSP00000418933 ENST00000480741	E7ETP6 [Direct mapping] Interleukin-24 Show all	Predicted intracellular proteins Show all	GO:0005125 [cytokine activity] GO:0005615 [extracellular space] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0046427 [positive regulation of JAK-STAT cascade] Show all	60 aa 7 kDa	No	0
IL24-201 ENSP00000484900 ENST00000611909	Q13007 [Direct mapping] Interleukin-24 Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0005125 [cytokine activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0046427 [positive regulation of JAK-STAT cascade] Show all	63 aa 7.3 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.