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CAPN2

GENERAL INFORMATION

Gene name

 CAPN2

Gene description

 Calpain 2, (m/II) large subunit

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several different cell types, including endothelial cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA024470
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), pancreatic cancer (unfavourable) and urothelial cancer (unfavourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA024470

GENE INFORMATION

Gene name

 CAPN2 (HGNC Symbol)

Synonyms

 CANPL2, CANPml, mCANP

Description

 Calpain 2, (m/II) large subunit (HGNC Symbol)

Entrez gene summary

 The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Chromosome

 1

Cytoband

 q41

Chromosome location (bp)

 223701593 - 223776018

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162909 (version 83.38)

Entrez gene

 824

UniProt

 P17655 (UniProt - Evidence at protein level)

neXtProt

 NX_P17655

Antibodypedia

 CAPN2 antibodies

PROTEIN BROWSER
CAPN2-001
CAPN2-009
CAPN2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CAPN2-001
ENSP00000295006
ENST00000295006
P17655 [Direct mapping]
Calpain-2 catalytic subunit
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000785 [chromatin]
GO:0001666 [response to hypoxia]
GO:0001824 [blastocyst development]
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006508 [proteolysis]
GO:0007520 [myoblast fusion]
GO:0008092 [cytoskeletal protein binding]
GO:0008233 [peptidase activity]
GO:0008234 [cysteine-type peptidase activity]
GO:0030425 [dendrite]
GO:0030864 [cortical actin cytoskeleton]
GO:0031143 [pseudopodium]
GO:0045121 [membrane raft]
GO:0046982 [protein heterodimerization activity]
GO:0051493 [regulation of cytoskeleton organization]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0070062 [extracellular exosome]
GO:0071230 [cellular response to amino acid stimulus]
GO:0097038 [perinuclear endoplasmic reticulum]
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 700 aa
80 kDa 		No 0
CAPN2-009
ENSP00000399949
ENST00000434648
C9JWY7 [Direct mapping]
Calpain-2 catalytic subunit
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005622 [intracellular]
GO:0006508 [proteolysis]
GO:0051493 [regulation of cytoskeleton organization]
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 131 aa
14.4 kDa 		No 0
CAPN2-201
ENSP00000413158
ENST00000433674
P17655 [Direct mapping]
Calpain-2 catalytic subunit
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006508 [proteolysis]
GO:0008092 [cytoskeletal protein binding]
GO:0008234 [cysteine-type peptidase activity]
GO:0030425 [dendrite]
GO:0030864 [cortical actin cytoskeleton]
GO:0031143 [pseudopodium]
GO:0045121 [membrane raft]
GO:0051493 [regulation of cytoskeleton organization]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0070062 [extracellular exosome]
GO:0071230 [cellular response to amino acid stimulus]
GO:0097038 [perinuclear endoplasmic reticulum]
Show all
 622 aa
71.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.