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REL

GENERAL INFORMATION

Gene name

 REL

Gene description

 V-rel avian reticuloendotheliosis viral oncogene homolog

Protein class

 Cancer-related genes
Predicted intracellular proteins
RAS pathway related proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues and in a subset of immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
CAB004404
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB004404

GENE INFORMATION

Gene name

 REL (HGNC Symbol)

Synonyms

 c-Rel, I-Rel

Description

 V-rel avian reticuloendotheliosis viral oncogene homolog (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

Chromosome

 2

Cytoband

 p16.1

Chromosome location (bp)

 60881521 - 60931610

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162924 (version 83.38)

Entrez gene

 5966

UniProt

 Q04864 (UniProt - Evidence at protein level)

neXtProt

 NX_Q04864

Antibodypedia

 REL antibodies

PROTEIN BROWSER
REL-001
REL-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
REL-001
ENSP00000295025
ENST00000295025
Q04864 [Direct mapping]
Proto-oncogene c-Rel
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Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0001816 [cytokine production]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006954 [inflammatory response]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0010629 [negative regulation of gene expression]
GO:0032688 [negative regulation of interferon-beta production]
GO:0033256 [I-kappaB/NF-kappaB complex]
GO:0034097 [response to cytokine]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043565 [sequence-specific DNA binding]
GO:0045084 [positive regulation of interleukin-12 biosynthetic process]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:1901215 [negative regulation of neuron death]
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 619 aa
68.5 kDa 		No 0
REL-002
ENSP00000377989
ENST00000394479
Q04864 [Direct mapping]
Proto-oncogene c-Rel
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Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006954 [inflammatory response]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0010629 [negative regulation of gene expression]
GO:0032688 [negative regulation of interferon-beta production]
GO:0033256 [I-kappaB/NF-kappaB complex]
GO:0034097 [response to cytokine]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
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 587 aa
65.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.