Expression of PEX13 in cancer - Summary - The Human Protein Atlas

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PEX13

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PEX13
Gene description	Peroxisomal biogenesis factor 13
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA032141 , HPA032142 , CAB032689
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA032141	HPA032142	CAB032689

GENE INFORMATION
Gene name	PEX13
Synonyms
Description	Peroxisomal biogenesis factor 13 (HGNC Symbol)
Entrez gene summary	This gene encodes a peroxisomal membrane protein that binds the type 1 peroxisomal targeting signal receptor via a SH3 domain located in the cytoplasm. Mutations and deficiencies in peroxisomal protein importing and peroxisome assembly lead to peroxisomal biogenesis disorders, an example of which is Zellweger syndrome. [provided by RefSeq, Oct 2008]
Chromosome	2
Cytoband	p15
Chromosome location (bp)	61017225 - 61051990
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162928 (version 83.38)
Entrez gene	5194
UniProt	Q92968 (UniProt - Evidence at protein level)
neXtProt	NX_Q92968
Antibodypedia	PEX13 antibodies

PROTEIN BROWSER

PEX13-001	PEX13-002	PEX13-003	PEX13-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PEX13-001 ENSP00000295030 ENST00000295030	Q92968 [Direct mapping] Peroxisomal membrane protein PEX13 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001561 [fatty acid alpha-oxidation] GO:0001764 [neuron migration] GO:0001967 [suckling behavior] GO:0002230 [positive regulation of defense response to virus by host] GO:0005515 [protein binding] GO:0005777 [peroxisome] GO:0005778 [peroxisomal membrane] GO:0005779 [integral component of peroxisomal membrane] GO:0007626 [locomotory behavior] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016560 [protein import into peroxisome matrix, docking] GO:0021795 [cerebral cortex cell migration] GO:0043231 [intracellular membrane-bounded organelle] GO:0060152 [microtubule-based peroxisome localization] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	403 aa 44.1 kDa	No	2
PEX13-002 ENSP00000405184 ENST00000444100	D3YTD3 [Direct mapping] Peroxisomal membrane protein PEX13; Peroxisome biogenesis factor 13, isoform CRA_e Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		63 aa 6.5 kDa	No	0
PEX13-003 ENSP00000405413 ENST00000414712	G5E9N6 [Direct mapping] Peroxisomal membrane protein PEX13; Peroxisome biogenesis factor 13, isoform CRA_d Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		54 aa 5.4 kDa	No	0
PEX13-005 ENSP00000384738 ENST00000401576	B5MBY9 [Direct mapping] Peroxisomal membrane protein PEX13; Peroxisome biogenesis factor 13, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		36 aa 3.7 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.