Expression of ARL5A in cancer - Summary - The Human Protein Atlas

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ARL5A

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ARL5A
Gene description	ADP-ribosylation factor-like 5A
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Approved based on 1 antibody. HPA027002
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA027002

GENE INFORMATION
Gene name	ARL5A (HGNC Symbol)
Synonyms	ARL5
Description	ADP-ribosylation factor-like 5A (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the ARF family of GTP-binding proteins. With its distinctive nuclear/nucleolar localization and interaction with HP1alpha, the protein is developmentally regulated and may play a role(s) in nuclear dynamics and/or signaling cascades during embryonic development. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q23.3
Chromosome location (bp)	151788984 - 151828492
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162980 (version 83.38)
Entrez gene	26225
UniProt	Q9Y689 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y689
Antibodypedia	ARL5A antibodies

PROTEIN BROWSER

ARL5A-001	ARL5A-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARL5A-001 ENSP00000295087 ENST00000295087	Q9Y689 [Direct mapping] ADP-ribosylation factor-like protein 5A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] GO:0007264 [small GTPase mediated signal transduction] Show all	179 aa 20.7 kDa	No	0
ARL5A-002 ENSP00000415950 ENST00000428992	Q9Y689 [Direct mapping] ADP-ribosylation factor-like protein 5A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] Show all	142 aa 16.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.