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ACTG2

GENERAL INFORMATION

Gene name

 ACTG2

Gene description

 Actin, gamma 2, smooth muscle, enteric

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (seminal vesicle, smooth muscle)
GTEx:Expressed in all
FANTOM5:Tissue enhanced (smooth muscle, urinary bladder)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic staining of myoepithelial cells

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 2 antibodies.
HPA041264 , HPA041271
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Smooth muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (seminal vesicle, smooth muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (smooth muscle, urinary bladder)

GENE INFORMATION

Gene name

 ACTG2 (HGNC Symbol)

Synonyms

 ACTA3, ACTL3, ACTSG

Description

 Actin, gamma 2, smooth muscle, enteric (HGNC Symbol)

Entrez gene summary

 Actins are highly conserved proteins that are involved in various types of cell motility and in the maintenance of the cytoskeleton. Three types of actins, alpha, beta and gamma, have been identified in vertebrates. Alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. This gene encodes actin gamma 2; a smooth muscle actin found in enteric tissues. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Based on similarity to peptide cleavage of related actins, the mature protein of this gene is formed by removal of two N-terminal peptides.[provided by RefSeq, Dec 2010]

Chromosome

 2

Cytoband

 p13.1

Chromosome location (bp)

 73892314 - 73919865

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163017 (version 83.38)

Entrez gene

 72

UniProt

 P63267 (UniProt - Evidence at protein level)

neXtProt

 NX_P63267

Antibodypedia

 ACTG2 antibodies

PROTEIN BROWSER
ACTG2-001
ACTG2-002
ACTG2-003
ACTG2-008
ACTG2-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACTG2-001
ENSP00000295137
ENST00000345517
P63267 [Direct mapping]
Actin, gamma-enteric smooth muscle
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006936 [muscle contraction]
GO:0010628 [positive regulation of gene expression]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0032982 [myosin filament]
GO:0044297 [cell body]
GO:0070062 [extracellular exosome]
GO:0072562 [blood microparticle]
GO:0090131 [mesenchyme migration]
Show all
 376 aa
41.9 kDa 		No 0
ACTG2-002
ENSP00000386857
ENST00000409624
P63267 [Direct mapping]
Actin, gamma-enteric smooth muscle
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006936 [muscle contraction]
GO:0010628 [positive regulation of gene expression]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0032982 [myosin filament]
GO:0044297 [cell body]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:0072562 [blood microparticle]
GO:0090131 [mesenchyme migration]
Show all
 376 aa
41.9 kDa 		No 0
ACTG2-003
ENSP00000387182
ENST00000409918
B8ZZJ2 [Direct mapping]
Actin, gamma-enteric smooth muscle
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 119 aa
13 kDa 		No 0
ACTG2-008
ENSP00000386929
ENST00000409731
P63267 [Direct mapping]
Actin, gamma-enteric smooth muscle
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006936 [muscle contraction]
GO:0010628 [positive regulation of gene expression]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0032982 [myosin filament]
GO:0044297 [cell body]
GO:0070062 [extracellular exosome]
GO:0072562 [blood microparticle]
GO:0090131 [mesenchyme migration]
Show all
 333 aa
37.1 kDa 		No 0
ACTG2-010
ENSP00000410020
ENST00000442912
C9JFL5 [Direct mapping]
Actin, gamma-enteric smooth muscle
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 145 aa
16.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.