Expression of C2orf44 in cancer - Summary - The Human Protein Atlas

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C2orf44

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	C2orf44
Gene description	Chromosome 2 open reading frame 44
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA041054
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and endometrial cancer (unfavourable).
Liver cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041054

GENE INFORMATION
Gene name	C2orf44 (HGNC Symbol)
Synonyms	FLJ21945
Description	Chromosome 2 open reading frame 44 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	p23.3
Chromosome location (bp)	24029340 - 24049575
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163026 (version 83.38)
Entrez gene	80304
UniProt	Q9H6R7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H6R7
Antibodypedia	C2orf44 antibodies

PROTEIN BROWSER

C2orf44-001	C2orf44-002	C2orf44-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C2orf44-001 ENSP00000295148 ENST00000295148	Q9H6R7 [Direct mapping] WD repeat and coiled-coil-containing protein C2orf44 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0019900 [kinase binding] GO:0051259 [protein oligomerization] Show all	721 aa 79.1 kDa	No	0
C2orf44-002 ENSP00000385816 ENST00000406895	Q9H6R7 [Direct mapping] WD repeat and coiled-coil-containing protein C2orf44 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0019900 [kinase binding] GO:0051259 [protein oligomerization] Show all	622 aa 68.5 kDa	No	0
C2orf44-003 ENSP00000413426 ENST00000443232	C9JYC1 [Direct mapping] WD repeat-containing protein C2orf44 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	174 aa 19 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.