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SMC6

GENERAL INFORMATION

Gene name

 SMC6

Gene description

 Structural maintenance of chromosomes 6

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA042733 , CAB037186
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042733
CAB037186

GENE INFORMATION

Gene name

 SMC6 (HGNC Symbol)

Synonyms

 FLJ22116, SMC6L1

Description

 Structural maintenance of chromosomes 6 (HGNC Symbol)

Entrez gene summary

Chromosome

 2

Cytoband

 p24.2

Chromosome location (bp)

 17663812 - 17800242

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163029 (version 83.38)

Entrez gene

 79677

UniProt

 Q96SB8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96SB8

Antibodypedia

 SMC6 antibodies

PROTEIN BROWSER
SMC6-001
SMC6-002
SMC6-003
SMC6-006
SMC6-007
SMC6-009
SMC6-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SMC6-001
ENSP00000323439
ENST00000351948
Q96SB8 [Direct mapping]
Structural maintenance of chromosomes protein 6
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000722 [telomere maintenance via recombination]
GO:0000781 [chromosome, telomeric region]
GO:0000803 [sex chromosome]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0016605 [PML body]
GO:0016925 [protein sumoylation]
GO:0030915 [Smc5-Smc6 complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0035061 [interchromatin granule]
GO:0035861 [site of double-strand break]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0051984 [positive regulation of chromosome segregation]
GO:0090398 [cellular senescence]
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 1091 aa
126.3 kDa 		No 0
SMC6-002
ENSP00000404092
ENST00000448223
Q96SB8 [Direct mapping]
Structural maintenance of chromosomes protein 6
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000722 [telomere maintenance via recombination]
GO:0000781 [chromosome, telomeric region]
GO:0000803 [sex chromosome]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0016605 [PML body]
GO:0016925 [protein sumoylation]
GO:0030915 [Smc5-Smc6 complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0035061 [interchromatin granule]
GO:0035861 [site of double-strand break]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0051984 [positive regulation of chromosome segregation]
GO:0090398 [cellular senescence]
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 1091 aa
126.3 kDa 		No 0
SMC6-003
ENSP00000408644
ENST00000446852
C9JMN1 [Direct mapping]
Structural maintenance of chromosomes protein 6
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   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
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 740 aa
84.5 kDa 		No 0
SMC6-006
ENSP00000384539
ENST00000402989
Q96SB8 [Direct mapping]
Structural maintenance of chromosomes protein 6
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000722 [telomere maintenance via recombination]
GO:0000781 [chromosome, telomeric region]
GO:0000803 [sex chromosome]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0016605 [PML body]
GO:0016925 [protein sumoylation]
GO:0030915 [Smc5-Smc6 complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0035061 [interchromatin granule]
GO:0035861 [site of double-strand break]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0051984 [positive regulation of chromosome segregation]
GO:0090398 [cellular senescence]
Show all
 1091 aa
126.3 kDa 		No 0
SMC6-007
ENSP00000415352
ENST00000428868
C9JEF0 [Direct mapping]
Structural maintenance of chromosomes protein 6
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 57 aa
6.5 kDa 		No 0
SMC6-009
ENSP00000480257
ENST00000621152
A0A087WWI9 [Direct mapping]
Structural maintenance of chromosomes protein 6
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 76 aa
8.6 kDa 		No 0
SMC6-010
ENSP00000370672
ENST00000381272
A0A0A0MRY1 [Direct mapping]
Structural maintenance of chromosomes protein 6
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 446 aa
51 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.