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H3F3A

GENERAL INFORMATION

Gene name

 H3F3A

Gene description

 H3 histone, family 3A

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 3 antibodies.
HPA042570 , CAB011481 , CAB037178
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042570
CAB011481
CAB037178

GENE INFORMATION

Gene name

 H3F3A (HGNC Symbol)

Synonyms

 H3.3A, H3F3

Description

 H3 histone, family 3A (HGNC Symbol)

Entrez gene summary

 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q42.12

Chromosome location (bp)

 226061851 - 226072001

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163041 (version 83.38)

Entrez gene

 3020

UniProt

 P84243 (UniProt - Evidence at protein level)

neXtProt

 NX_P84243

Antibodypedia

 H3F3A antibodies

PROTEIN BROWSER
H3F3A-001
H3F3A-002
H3F3A-003
H3F3A-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
H3F3A-001
ENSP00000355780
ENST00000366815
P84243 [Direct mapping]
Histone H3.3
B2R4P9 [Target identity:100%; Query identity:100%]
Histone H3
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Show all
GO:0000183 [chromatin silencing at rDNA]
GO:0000228 [nuclear chromosome]
GO:0000786 [nucleosome]
GO:0000788 [nuclear nucleosome]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006334 [nucleosome assembly]
GO:0006336 [DNA replication-independent nucleosome assembly]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0010467 [gene expression]
GO:0030307 [positive regulation of cell growth]
GO:0031047 [gene silencing by RNA]
GO:0031492 [nucleosomal DNA binding]
GO:0032776 [DNA methylation on cytosine]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042393 [histone binding]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0046982 [protein heterodimerization activity]
GO:0070062 [extracellular exosome]
Show all
 136 aa
15.3 kDa 		No 0
H3F3A-002
ENSP00000355778
ENST00000366813
P84243 [Direct mapping]
Histone H3.3
B2R4P9 [Target identity:100%; Query identity:100%]
Histone H3
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Show all
GO:0000183 [chromatin silencing at rDNA]
GO:0000228 [nuclear chromosome]
GO:0000786 [nucleosome]
GO:0000788 [nuclear nucleosome]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006334 [nucleosome assembly]
GO:0006336 [DNA replication-independent nucleosome assembly]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007420 [brain development]
GO:0007596 [blood coagulation]
GO:0009725 [response to hormone]
GO:0010467 [gene expression]
GO:0030307 [positive regulation of cell growth]
GO:0031047 [gene silencing by RNA]
GO:0031492 [nucleosomal DNA binding]
GO:0032776 [DNA methylation on cytosine]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042393 [histone binding]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0046982 [protein heterodimerization activity]
GO:0070062 [extracellular exosome]
Show all
 136 aa
15.3 kDa 		No 0
H3F3A-003
ENSP00000355779
ENST00000366814
B4DEB1 [Direct mapping]
Histone H3
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Show all
GO:0000786 [nucleosome]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0046982 [protein heterodimerization activity]
Show all
 123 aa
14.1 kDa 		No 0
H3F3A-004
ENSP00000355781
ENST00000366816
P84243 [Direct mapping]
Histone H3.3
B2R4P9 [Target identity:100%; Query identity:100%]
Histone H3
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Show all
GO:0000183 [chromatin silencing at rDNA]
GO:0000228 [nuclear chromosome]
GO:0000786 [nucleosome]
GO:0000788 [nuclear nucleosome]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006334 [nucleosome assembly]
GO:0006336 [DNA replication-independent nucleosome assembly]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0010467 [gene expression]
GO:0030307 [positive regulation of cell growth]
GO:0031047 [gene silencing by RNA]
GO:0031492 [nucleosomal DNA binding]
GO:0032776 [DNA methylation on cytosine]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042393 [histone binding]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0046982 [protein heterodimerization activity]
GO:0070062 [extracellular exosome]
Show all
 136 aa
15.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.