Cell atlas - ADCK3 - The Human Protein Atlas

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ADCK3

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	ADCK3
Gene description	AarF domain containing kinase 3
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA061662
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA061662	Hep G2	Mitochondria
	HPA061662	U-2 OS	No staining

GENE INFORMATION
Gene name	ADCK3 (HGNC Symbol)
Synonyms	CABC1, COQ8, SCAR9
Description	AarF domain containing kinase 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found; however, their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q42.13
Chromosome location (bp)	226897536 - 226987545
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163050 (version 83.38)
Entrez gene	56997
UniProt	Q8NI60 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NI60
Antibodypedia	ADCK3 antibodies

PROTEIN BROWSER

ADCK3-001	ADCK3-004	ADCK3-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADCK3-001 ENSP00000355739 ENST00000366777	Q8NI60 [Direct mapping] Atypical kinase ADCK3, mitochondrial A0A024R3S3 [Target identity:100%; Query identity:100%] Chaperone, ABC1 activity of bc1 complex like (S. pombe), isoform CRA_b Show all	Enzymes Kinases Atypical kinases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0006744 [ubiquinone biosynthetic process] GO:0016021 [integral component of membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0043531 [ADP binding] Show all	647 aa 71.9 kDa	No	0
ADCK3-004 ENSP00000355741 ENST00000366779	Q8NI60 [Direct mapping] Atypical kinase ADCK3, mitochondrial A0A024R3S3 [Target identity:100%; Query identity:100%] Chaperone, ABC1 activity of bc1 complex like (S. pombe), isoform CRA_b Show all	Enzymes Kinases Atypical kinases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0006744 [ubiquinone biosynthetic process] GO:0016021 [integral component of membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0043531 [ADP binding] Show all	647 aa 71.9 kDa	No	0
ADCK3-013 ENSP00000355740 ENST00000366778	Q8NI60 [Direct mapping] Atypical kinase ADCK3, mitochondrial Show all	Enzymes Kinases Atypical kinases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0006744 [ubiquinone biosynthetic process] GO:0016021 [integral component of membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0043531 [ADP binding] Show all	595 aa 66.6 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.