Expression of SGCB in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SGCB
Gene description	Sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in skeletal muscle and smooth muscle, highest expression in heart.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 1 antibody. HPA011422
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and urothelial cancer (unfavourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA011422

GENE INFORMATION
Gene name	SGCB (HGNC Symbol)
Synonyms	A3b, LGMD2E, SGC
Description	Sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy.[provided by RefSeq, Oct 2008]
Chromosome	4
Cytoband	q12
Chromosome location (bp)	52020706 - 52038482
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163069 (version 83.38)
Entrez gene	6443
UniProt	Q16585 (UniProt - Evidence at protein level)
neXtProt	NX_Q16585
Antibodypedia	SGCB antibodies

PROTEIN BROWSER

SGCB-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SGCB-001 ENSP00000370839 ENST00000381431	Q16585 [Direct mapping] Beta-sarcoglycan Q5U0N0 [Target identity:100%; Query identity:100%] Sarcoglycan, beta (43kDa dystrophin-associated glycoprotein); Sarcoglycan, beta (43kDa dystrophin-associated glycoprotein), isoform CRA_a; cDNA FLJ75413, highly similar to Homo sapiens sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) (SGCB), mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005887 [integral component of plasma membrane] GO:0007517 [muscle organ development] GO:0016010 [dystrophin-associated glycoprotein complex] GO:0016011 [dystroglycan complex] GO:0016012 [sarcoglycan complex] GO:0016021 [integral component of membrane] GO:0042383 [sarcolemma] GO:0048747 [muscle fiber development] GO:0055013 [cardiac muscle cell development] GO:0097084 [vascular smooth muscle cell development] Show all	318 aa 34.8 kDa	No	1