Expression of XIRP2 in cancer - Summary - The Human Protein Atlas

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XIRP2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	XIRP2
Gene description	Xin actin binding repeat containing 2
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (head and neck cancer)
HPA (cell line):	Cell line enhanced (AN3-CA, HUVEC TERT2, U-2197)
HPA (normal tissue):	Group enriched (heart muscle, skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA034813
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (head and neck cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA034813

GENE INFORMATION
Gene name	XIRP2 (HGNC Symbol)
Synonyms	CMYA3
Description	Xin actin binding repeat containing 2 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	q24.3
Chromosome location (bp)	166888487 - 167259753
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163092 (version 83.38)
Entrez gene	129446
UniProt	A4UGR9 (UniProt - Evidence at protein level)
neXtProt	NX_A4UGR9
Antibodypedia	XIRP2 antibodies

PROTEIN BROWSER

XIRP2-001	XIRP2-002	XIRP2-005	XIRP2-006	XIRP2-007	XIRP2-201	XIRP2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
XIRP2-001 ENSP00000386840 ENST00000409195	A4UGR9 [Direct mapping] Xin actin-binding repeat-containing protein 2 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003281 [ventricular septum development] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0030018 [Z disc] GO:0030036 [actin cytoskeleton organization] GO:0030054 [cell junction] GO:0045216 [cell-cell junction organization] GO:0051393 [alpha-actinin binding] GO:0055008 [cardiac muscle tissue morphogenesis] Show all	3549 aa 402.1 kDa	No	0
XIRP2-002 ENSP00000386454 ENST00000409043	A4UGR9 [Direct mapping] Xin actin-binding repeat-containing protein 2 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0008270 [zinc ion binding] GO:0030036 [actin cytoskeleton organization] GO:0030054 [cell junction] Show all	938 aa 106.6 kDa	No	0
XIRP2-005 ENSP00000387255 ENST00000409273	A4UGR9 [Direct mapping] Xin actin-binding repeat-containing protein 2 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0030036 [actin cytoskeleton organization] GO:0030054 [cell junction] Show all	3327 aa 377.3 kDa	No	0
XIRP2-006 ENSP00000386619 ENST00000409728	A4UGR9 [Direct mapping] Xin actin-binding repeat-containing protein 2 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0008270 [zinc ion binding] GO:0030036 [actin cytoskeleton organization] GO:0030054 [cell junction] Show all	971 aa 110.3 kDa	No	0
XIRP2-007 ENSP00000386981 ENST00000409605	A4UGR9 [Direct mapping] Xin actin-binding repeat-containing protein 2 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0008270 [zinc ion binding] GO:0030036 [actin cytoskeleton organization] GO:0030054 [cell junction] Show all	716 aa 81.8 kDa	No	0
XIRP2-201 ENSP00000295237 ENST00000295237	A0A0A0MQZ3 [Direct mapping] Xin actin-binding repeat-containing protein 2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0007507 [heart development] GO:0030036 [actin cytoskeleton organization] Show all	963 aa 108.9 kDa	No	0
XIRP2-202 ENSP00000486198 ENST00000628543	A4UGR9 [Direct mapping] Xin actin-binding repeat-containing protein 2 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0030036 [actin cytoskeleton organization] GO:0030054 [cell junction] Show all	3374 aa 382.3 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.