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HPGDS

GENERAL INFORMATION

Gene name

 HPGDS

Gene description

 Hematopoietic prostaglandin D synthase

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (placenta)
GTEx:Mixed
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in mast cells, megakaryocytes, macrophages and thyroid gland.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 1 antibody.
HPA024035
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Lung

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 HPGDS (HGNC Symbol)

Synonyms

 GSTS, GSTS1, GSTS1-1, H-PGDS, PGD2, PGDS

Description

 Hematopoietic prostaglandin D synthase (HGNC Symbol)

Entrez gene summary

 Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q22.3

Chromosome location (bp)

 94298535 - 94342876

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163106 (version 83.38)

Entrez gene

 27306

UniProt

 O60760 (UniProt - Evidence at protein level)

neXtProt

 NX_O60760

Antibodypedia

 HPGDS antibodies

PROTEIN BROWSER
HPGDS-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HPGDS-001
ENSP00000295256
ENST00000295256
O60760 [Direct mapping]
Hematopoietic prostaglandin D synthase
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Enzymes
   ENZYME proteins
   Transferases
   Isomerase
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004364 [glutathione transferase activity]
GO:0004667 [prostaglandin-D synthase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006693 [prostaglandin metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0007165 [signal transduction]
GO:0007626 [locomotory behavior]
GO:0019369 [arachidonic acid metabolic process]
GO:0019371 [cyclooxygenase pathway]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:1901687 [glutathione derivative biosynthetic process]
GO:2000255 [negative regulation of male germ cell proliferation]
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 199 aa
23.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.