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PDHA2

GENERAL INFORMATION

Gene name

 PDHA2

Gene description

 Pyruvate dehydrogenase (lipoamide) alpha 2

Protein class

 Citric acid cycle related proteins
Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in cells of seminiferous ducts.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Approved based on 3 antibodies.
HPA047487 , HPA047864 , HPA063053
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA047487
HPA047864
HPA063053

GENE INFORMATION

Gene name

 PDHA2 (HGNC Symbol)

Synonyms

 PDHAL

Description

 Pyruvate dehydrogenase (lipoamide) alpha 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 4

Cytoband

 q22.3

Chromosome location (bp)

 95840019 - 95841474

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163114 (version 83.38)

Entrez gene

 5161

UniProt

 P29803 (UniProt - Evidence at protein level)

neXtProt

 NX_P29803

Antibodypedia

 PDHA2 antibodies

PROTEIN BROWSER
PDHA2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDHA2-001
ENSP00000295266
ENST00000295266
P29803 [Direct mapping]
Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004739 [pyruvate dehydrogenase (acetyl-transferring) activity]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006006 [glucose metabolic process]
GO:0006086 [acetyl-CoA biosynthetic process from pyruvate]
GO:0006090 [pyruvate metabolic process]
GO:0006099 [tricarboxylic acid cycle]
GO:0008152 [metabolic process]
GO:0016624 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045254 [pyruvate dehydrogenase complex]
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 388 aa
42.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.