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CTSS

GENERAL INFORMATION

Gene name

 CTSS

Gene description

 Cathepsin S

Protein class

 Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HMC-1, U-698)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues, highly abundant in subsets of immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA002988 , CAB000460
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Stomach cancer

STAINING SUMMARY
HPA002988
CAB000460

GENE INFORMATION

Gene name

 CTSS

Synonyms

Description

 Cathepsin S (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 150730196 - 150765957

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163131 (version 83.38)

Entrez gene

 1520

UniProt

 P25774 (UniProt - Evidence at protein level)

neXtProt

 NX_P25774

Antibodypedia

 CTSS antibodies

PROTEIN BROWSER
CTSS-001
CTSS-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CTSS-001
ENSP00000357981
ENST00000368985
P25774 [Direct mapping]
Cathepsin S
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001968 [fibronectin binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002480 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005764 [lysosome]
GO:0006508 [proteolysis]
GO:0006955 [immune response]
GO:0008233 [peptidase activity]
GO:0008234 [cysteine-type peptidase activity]
GO:0010447 [response to acidic pH]
GO:0016020 [membrane]
GO:0016485 [protein processing]
GO:0019882 [antigen processing and presentation]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030574 [collagen catabolic process]
GO:0034769 [basement membrane disassembly]
GO:0036021 [endolysosome lumen]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0043202 [lysosomal lumen]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043236 [laminin binding]
GO:0043394 [proteoglycan binding]
GO:0045087 [innate immune response]
GO:0048002 [antigen processing and presentation of peptide antigen]
GO:0050729 [positive regulation of inflammatory response]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0097067 [cellular response to thyroid hormone stimulus]
GO:2001259 [positive regulation of cation channel activity]
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 331 aa
37.5 kDa 		Yes 0
CTSS-006
ENSP00000408414
ENST00000448301
P25774 [Direct mapping]
Cathepsin S
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001968 [fibronectin binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002480 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005764 [lysosome]
GO:0006508 [proteolysis]
GO:0006955 [immune response]
GO:0008234 [cysteine-type peptidase activity]
GO:0010447 [response to acidic pH]
GO:0016485 [protein processing]
GO:0019882 [antigen processing and presentation]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030574 [collagen catabolic process]
GO:0034769 [basement membrane disassembly]
GO:0036021 [endolysosome lumen]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0043202 [lysosomal lumen]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043236 [laminin binding]
GO:0043394 [proteoglycan binding]
GO:0045087 [innate immune response]
GO:0048002 [antigen processing and presentation of peptide antigen]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0097067 [cellular response to thyroid hormone stimulus]
GO:2001259 [positive regulation of cation channel activity]
Show all
 281 aa
31.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.