Expression of BNIPL in cancer - Summary - The Human Protein Atlas

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BNIPL

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	BNIPL
Gene description	BCL2/adenovirus E1B 19kD interacting protein like
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enriched (T-47d)
HPA (normal tissue):	Group enriched (esophagus, skin)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (favourable) and endometrial cancer (unfavourable).
Thyroid cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	BNIPL (HGNC Symbol)
Synonyms	BNIPl-1, BNIPL-2, PP753
Description	BCL2/adenovirus E1B 19kD interacting protein like (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene interacts with several other proteins, such as BCL2, ARHGAP1, MIF and GFER. It may function as a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	151036570 - 151047600
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163141 (version 83.38)
Entrez gene	149428
UniProt	Q7Z465 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z465
Antibodypedia	BNIPL antibodies

PROTEIN BROWSER

BNIPL-001	BNIPL-002	BNIPL-003	BNIPL-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BNIPL-001 ENSP00000357927 ENST00000368931	Q7Z465 [Direct mapping] Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006915 [apoptotic process] GO:0008285 [negative regulation of cell proliferation] GO:0040009 [regulation of growth rate] GO:0042802 [identical protein binding] Show all	357 aa 39.7 kDa	No	1
BNIPL-002 ENSP00000295294 ENST00000295294	Q7Z465 [Direct mapping] Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006915 [apoptotic process] GO:0008285 [negative regulation of cell proliferation] GO:0040009 [regulation of growth rate] GO:0042802 [identical protein binding] Show all	275 aa 31 kDa	No	1
BNIPL-003 ENSP00000376550 ENST00000392802	F8W685 [Direct mapping] Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		100 aa 11 kDa	No	0
BNIPL-006 ENSP00000355333 ENST00000361277	A2A492 [Direct mapping] Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		341 aa 38.1 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.