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SPRR3

GENERAL INFORMATION

Gene name

 SPRR3

Gene description

 Small proline-rich protein 3

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (head and neck cancer)
HPA (cell line):Cell line enhanced (CAPAN-2, hTCEpi, RT4)
HPA (normal tissue):Tissue enriched (esophagus)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in squamous tissue.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA044467
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA044467

GENE INFORMATION

Gene name

 SPRR3

Synonyms

Description

 Small proline-rich protein 3 (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 153001747 - 153003856

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163209 (version 83.38)

Entrez gene

 6707

UniProt

 Q9UBC9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UBC9

Antibodypedia

 SPRR3 antibodies

PROTEIN BROWSER
SPRR3-001
SPRR3-003
SPRR3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SPRR3-001
ENSP00000295367
ENST00000295367
Q9UBC9 [Direct mapping]
Small proline-rich protein 3
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Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001533 [cornified envelope]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0008544 [epidermis development]
GO:0018149 [peptide cross-linking]
GO:0030216 [keratinocyte differentiation]
GO:0031424 [keratinization]
GO:0042060 [wound healing]
GO:0070062 [extracellular exosome]
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 169 aa
18.2 kDa 		No 0
SPRR3-003
ENSP00000402016
ENST00000443178
B1AN48 [Direct mapping]
Small proline-rich protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 159 aa
17.1 kDa 		No 0
SPRR3-201
ENSP00000330391
ENST00000331860
Q9UBC9 [Direct mapping]
Small proline-rich protein 3
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001533 [cornified envelope]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0008544 [epidermis development]
GO:0018149 [peptide cross-linking]
GO:0030216 [keratinocyte differentiation]
GO:0031424 [keratinization]
GO:0042060 [wound healing]
GO:0070062 [extracellular exosome]
Show all
 169 aa
18.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.