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BMP10

GENERAL INFORMATION

Gene name

 BMP10

Gene description

 Bone morphogenetic protein 10

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (heart muscle)
GTEx:Tissue enriched (heart muscle)
FANTOM5:Group enriched (heart muscle, liver)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (heart muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (heart muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (heart muscle, liver)

GENE INFORMATION

Gene name

 BMP10

Synonyms

Description

 Bone morphogenetic protein 10 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the TGF-beta family of growth factors. Data suggest that the similar protein in mouse plays an important role in trabeculation of the embryonic heart. In human, this protein may signal through receptor serine/threonine kinases. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p13.3

Chromosome location (bp)

 68865481 - 68871517

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163217 (version 83.38)

Entrez gene

 27302

UniProt

 O95393 (UniProt - Evidence at protein level)

neXtProt

 NX_O95393

Antibodypedia

 BMP10 antibodies

PROTEIN BROWSER
BMP10-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BMP10-001
ENSP00000295379
ENST00000295379
O95393 [Direct mapping]
Bone morphogenetic protein 10
Show all
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005125 [cytokine activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0007155 [cell adhesion]
GO:0007507 [heart development]
GO:0007512 [adult heart development]
GO:0008083 [growth factor activity]
GO:0009986 [cell surface]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0010614 [negative regulation of cardiac muscle hypertrophy]
GO:0010628 [positive regulation of gene expression]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0030018 [Z disc]
GO:0030198 [extracellular matrix organization]
GO:0030308 [negative regulation of cell growth]
GO:0030336 [negative regulation of cell migration]
GO:0030509 [BMP signaling pathway]
GO:0031433 [telethonin binding]
GO:0032924 [activin receptor signaling pathway]
GO:0033612 [receptor serine/threonine kinase binding]
GO:0040007 [growth]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0045214 [sarcomere organization]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048468 [cell development]
GO:0055009 [atrial cardiac muscle tissue morphogenesis]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0055015 [ventricular cardiac muscle cell development]
GO:0055117 [regulation of cardiac muscle contraction]
GO:0060038 [cardiac muscle cell proliferation]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060298 [positive regulation of sarcomere organization]
GO:0060347 [heart trabecula formation]
GO:0060389 [pathway-restricted SMAD protein phosphorylation]
GO:0060395 [SMAD protein signal transduction]
GO:0061036 [positive regulation of cartilage development]
GO:1903242 [regulation of cardiac muscle hypertrophy in response to stress]
GO:2000138 [positive regulation of cell proliferation involved in heart morphogenesis]
Show all
 424 aa
48 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.