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Most malignancies showed moderate cytoplasmic positivity. Few cases of skin cancer were strongly stained. Lung cancer, malignant glioma and lymphoma were generally weakly stained or negative.
GENE INFORMATION
Gene name
NPPC (HGNC Symbol)
Synonyms
CNP
Description
Natriuretic peptide C (HGNC Symbol)
Entrez gene summary
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. [provided by RefSeq, Oct 2015]