Tissue expression of GNPDA2 - Summary - The Human Protein Atlas

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GNPDA2

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	GNPDA2
Gene description	Glucosamine-6-phosphate deaminase 2
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 2 antibodies. HPA000499 , HPA046891
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	GNPDA2 (HGNC Symbol)
Synonyms	SB52
Description	Glucosamine-6-phosphate deaminase 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an allosteric enzyme that catalyzes the reversible reaction converting D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium. Variations of this gene have been reported to be associated with influencing body mass index and susceptibility to obesity. A pseudogene of this gene is located on chromosome 9. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
Chromosome	4
Cytoband	p12
Chromosome location (bp)	44682200 - 44726595
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163281 (version 83.38)
Entrez gene	132789
UniProt	Q8TDQ7 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TDQ7
Antibodypedia	GNPDA2 antibodies

PROTEIN BROWSER

GNPDA2-001	GNPDA2-002	GNPDA2-005	GNPDA2-006	GNPDA2-009	GNPDA2-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GNPDA2-001 ENSP00000295448 ENST00000295448	Q8TDQ7 [Direct mapping] Glucosamine-6-phosphate isomerase 2 A0A024R9X5 [Target identity:100%; Query identity:100%] Glucosamine-6-phosphate isomerase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004342 [glucosamine-6-phosphate deaminase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005975 [carbohydrate metabolic process] GO:0006044 [N-acetylglucosamine metabolic process] GO:0016787 [hydrolase activity] Show all	276 aa 31.1 kDa	No	0
GNPDA2-002 ENSP00000425868 ENST00000507917	Q8TDQ7 [Direct mapping] Glucosamine-6-phosphate isomerase 2 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004342 [glucosamine-6-phosphate deaminase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005975 [carbohydrate metabolic process] GO:0006044 [N-acetylglucosamine metabolic process] GO:0016787 [hydrolase activity] Show all	242 aa 27.1 kDa	No	0
GNPDA2-005 ENSP00000427423 ENST00000507534	Q8TDQ7 [Direct mapping] Glucosamine-6-phosphate isomerase 2 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004342 [glucosamine-6-phosphate deaminase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005975 [carbohydrate metabolic process] GO:0006044 [N-acetylglucosamine metabolic process] GO:0016787 [hydrolase activity] Show all	206 aa 22.9 kDa	No	0
GNPDA2-006 ENSP00000424061 ENST00000509756	Q8TDQ7 [Direct mapping] Glucosamine-6-phosphate isomerase 2 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004342 [glucosamine-6-phosphate deaminase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005975 [carbohydrate metabolic process] GO:0006044 [N-acetylglucosamine metabolic process] GO:0016787 [hydrolase activity] Show all	259 aa 29.2 kDa	No	0
GNPDA2-009 ENSP00000477137 ENST00000608855	V9GYW0 [Direct mapping] Glucosamine-6-phosphate isomerase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004342 [glucosamine-6-phosphate deaminase activity] GO:0006044 [N-acetylglucosamine metabolic process] Show all	63 aa 7.4 kDa	No	0
GNPDA2-010 ENSP00000476853 ENST00000609092	V9GYK3 [Direct mapping] Glucosamine-6-phosphate isomerase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004342 [glucosamine-6-phosphate deaminase activity] GO:0006044 [N-acetylglucosamine metabolic process] Show all	117 aa 13 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.