Expression of NIPAL1 in cancer - Summary - The Human Protein Atlas

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NIPAL1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NIPAL1
Gene description	NIPA-like domain containing 1
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (A-431, HaCaT, RT4)
HPA (normal tissue):	Tissue enhanced (esophagus, skin)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Cytoplasmic expression in skin keratinocytes, kidney and most glandular cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA036765
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036765

GENE INFORMATION
Gene name	NIPAL1 (HGNC Symbol)
Synonyms	DKFZp686A06115, NPAL1
Description	NIPA-like domain containing 1 (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	p12
Chromosome location (bp)	47914142 - 48040173
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000163293 (version 83.38)
Entrez gene	152519
UniProt	Q6NVV3 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6NVV3
Antibodypedia	NIPAL1 antibodies

PROTEIN BROWSER

NIPAL1-001	NIPAL1-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NIPAL1-001 ENSP00000295461 ENST00000295461	Q6NVV3 [Direct mapping] Magnesium transporter NIPA3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Show all	GO:0015095 [magnesium ion transmembrane transporter activity] GO:0015693 [magnesium ion transport] GO:0016021 [integral component of membrane] GO:1903830 [magnesium ion transmembrane transport] Show all	410 aa 44.6 kDa	No	9
NIPAL1-012 ENSP00000422276 ENST00000511123	H0Y8W0 [Direct mapping] Magnesium transporter NIPA3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0015095 [magnesium ion transmembrane transporter activity] GO:0015693 [magnesium ion transport] GO:0016021 [integral component of membrane] GO:1903830 [magnesium ion transmembrane transport] Show all	92 aa 10 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.