Distinct cytoplasmic and membranous staining was observed in testicular cancers as well as cases of endometrial cancers. Fractions of cells in cases of ovarian, cervical and gastric cancers exhibited moderate to strong cytoplasmic and membranous staining. Remaining cancers were negative.
Several cases of hepatocellular carcinomas and endometrial cancers along with a case of gastric cancer displayed strong cytoplasmic positivity. A few testicular cancers showed moderate cytoplasmic and membranous staining. Remaining cancers were negative.
Cases of seminomas, endometrial and ovarian cancers displayed moderate to strong luminal membranous and cytoplasmic immunoreactivity. Remaining cancers were negative.
Alkaline phosphatase, intestinal (HGNC Symbol)
Entrez gene summary
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border enzyme. This enzyme is a component of the gut mucosal defense system and is thought to function in the detoxification of lipopolysaccharide, and in the prevention of bacterial translocation in the gut. [provided by RefSeq, Dec 2014]