Fields »
ABOUT
HELP
BLOG
ALPI

GENERAL INFORMATION

Gene name

 ALPI

Gene description

 Alkaline phosphatase, intestinal

Protein class

 Enzymes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (liver cancer)
HPA (cell line):Cell line enriched (CACO-2)
HPA (normal tissue):Group enriched (duodenum, small intestine)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Membranous expression in duodenum and small intestine.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 3 antibodies.
HPA038764 , HPA038765 , HPA051699
SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038764
HPA038765
HPA051699

GENE INFORMATION

Gene name

 ALPI

Synonyms

Description

 Alkaline phosphatase, intestinal (HGNC Symbol)

Entrez gene summary

 There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border enzyme. This enzyme is a component of the gut mucosal defense system and is thought to function in the detoxification of lipopolysaccharide, and in the prevention of bacterial translocation in the gut. [provided by RefSeq, Dec 2014]

Chromosome

 2

Cytoband

 q37.1

Chromosome location (bp)

 232456123 - 232460032

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163295 (version 83.38)

Entrez gene

 248

UniProt

 P09923 (UniProt - Evidence at protein level)

neXtProt

 NX_P09923

Antibodypedia

 ALPI antibodies

PROTEIN BROWSER
ALPI-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALPI-001
ENSP00000295463
ENST00000295463
P09923 [Direct mapping]
Intestinal-type alkaline phosphatase
A0A024R4A2 [Target identity:100%; Query identity:100%]
Alkaline phosphatase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0002020 [protease binding]
GO:0003824 [catalytic activity]
GO:0004035 [alkaline phosphatase activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0031225 [anchored component of membrane]
Show all
 528 aa
56.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.