Expression of ANTXR2 in cancer - Summary - The Human Protein Atlas

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ANTXR2

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	ANTXR2
Gene description	Anthrax toxin receptor 2
Protein class	Disease related genes Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (LHCN-M2, U-2197)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	ANTXR2 (HGNC Symbol)
Synonyms	CMG-2, CMG2, FLJ31074
Description	Anthrax toxin receptor 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a receptor for anthrax toxin. The protein binds to collagen IV and laminin, suggesting that it may be involved in extracellular matrix adhesion. Mutations in this gene cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Chromosome	4
Cytoband	q21.21
Chromosome location (bp)	79901149 - 80125454
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163297 (version 83.38)
Entrez gene	118429
UniProt	P58335 (UniProt - Evidence at protein level)
neXtProt	NX_P58335
Antibodypedia	ANTXR2 antibodies

PROTEIN BROWSER

ANTXR2-001	ANTXR2-002	ANTXR2-003	ANTXR2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANTXR2-001 ENSP00000306185 ENST00000307333	P58335 [Direct mapping] Anthrax toxin receptor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0016021 [integral component of membrane] GO:0022414 [reproductive process] GO:0046872 [metal ion binding] GO:1901998 [toxin transport] Show all	489 aa 53.7 kDa	Yes	1
ANTXR2-002 ENSP00000314883 ENST00000346652	P58335 [Direct mapping] Anthrax toxin receptor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0010008 [endosome membrane] GO:0016021 [integral component of membrane] GO:0046872 [metal ion binding] Show all	386 aa 42.9 kDa	Yes	1
ANTXR2-003 ENSP00000384028 ENST00000404191	J3KPY9 [Direct mapping] Anthrax toxin receptor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0016021 [integral component of membrane] GO:0046872 [metal ion binding] Show all	411 aa 44.8 kDa	No	1
ANTXR2-004 ENSP00000385575 ENST00000403729	P58335 [Direct mapping] Anthrax toxin receptor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0010008 [endosome membrane] GO:0016021 [integral component of membrane] GO:0046872 [metal ion binding] Show all	488 aa 53.5 kDa	Yes	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.