Expression of HELQ in cancer - Summary - The Human Protein Atlas

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HELQ

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HELQ
Gene description	Helicase, POLQ-like
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA036853
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and pancreatic cancer (favourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036853

GENE INFORMATION
Gene name	HELQ (HGNC Symbol)
Synonyms	Hel308
Description	Helicase, POLQ-like (HGNC Symbol)
Entrez gene summary	HEL308 is a single-stranded DNA-dependent ATPase and DNA helicase (Marini and Wood, 2002 [PubMed 11751861]).[supplied by OMIM, Mar 2008]
Chromosome	4
Cytoband	q21.23
Chromosome location (bp)	83407343 - 83455856
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163312 (version 83.38)
Entrez gene	113510
UniProt	Q8TDG4 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TDG4
Antibodypedia	HELQ antibodies

PROTEIN BROWSER

HELQ-001	HELQ-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HELQ-001 ENSP00000295488 ENST00000295488	Q8TDG4 [Direct mapping] Helicase POLQ-like Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000724 [double-strand break repair via homologous recombination] GO:0003676 [nucleic acid binding] GO:0004386 [helicase activity] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] Show all	1101 aa 124.1 kDa	No	0
HELQ-002 ENSP00000424539 ENST00000510985	E3W980 [Direct mapping] Helicase POLQ-like Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] Show all	1034 aa 116.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.