Expression of GPR155 in cancer - Summary - The Human Protein Atlas

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GPR155

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GPR155
Gene description	G protein-coupled receptor 155
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (U-266/70)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, including stomach.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA036159
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036159

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Weak to moderate cytoplasmic and membranous staining was observed in several prostate cancers and melanomas. Remaining cancer tissues were in general negative.

GENE INFORMATION
Gene name	GPR155 (HGNC Symbol)
Synonyms	DEP.7, DEPDC3, FLJ31819, PGR22
Description	G protein-coupled receptor 155 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	q31.1
Chromosome location (bp)	174431571 - 174487094
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163328 (version 83.38)
Entrez gene	151556
UniProt	Q7Z3F1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q7Z3F1
Antibodypedia	GPR155 antibodies

PROTEIN BROWSER

GPR155-001	GPR155-002	GPR155-003	GPR155-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPR155-001 ENSP00000376335 ENST00000392552	Q7Z3F1 [Direct mapping] Integral membrane protein GPR155 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0003674 [molecular_function] GO:0005622 [intracellular] GO:0016021 [integral component of membrane] GO:0035556 [intracellular signal transduction] GO:0050890 [cognition] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] Show all	870 aa 96.9 kDa	No	>9
GPR155-002 ENSP00000295500 ENST00000295500	Q7Z3F1 [Direct mapping] Integral membrane protein GPR155 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0003674 [molecular_function] GO:0005622 [intracellular] GO:0016021 [integral component of membrane] GO:0035556 [intracellular signal transduction] GO:0050890 [cognition] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] Show all	870 aa 96.9 kDa	No	>9
GPR155-003 ENSP00000376334 ENST00000392551	Q7Z3F1 [Direct mapping] Integral membrane protein GPR155 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0003674 [molecular_function] GO:0005622 [intracellular] GO:0016021 [integral component of membrane] GO:0035556 [intracellular signal transduction] GO:0050890 [cognition] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] Show all	870 aa 96.9 kDa	No	>9
GPR155-201 ENSP00000481104 ENST00000614352	A0A087WXK4 [Direct mapping] Integral membrane protein GPR155 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005622 [intracellular] GO:0016021 [integral component of membrane] GO:0035556 [intracellular signal transduction] GO:0055085 [transmembrane transport] Show all	842 aa 93.7 kDa	No	>9

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.