Expression of PBXIP1 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

PBXIP1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PBXIP1
Gene description	Pre-B-cell leukemia homeobox interacting protein 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enriched (Karpas-707)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA006949
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), pancreatic cancer (favourable), colorectal cancer (unfavourable), head and neck cancer (favourable) and lung cancer (favourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Colorectal cancer p<0.001 Head and neck cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA006949

GENE INFORMATION
Gene name	PBXIP1 (HGNC Symbol)
Synonyms	HPIP
Description	Pre-B-cell leukemia homeobox interacting protein 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast cancer, brain tumors, and lung cancer. Several transcript variants encoding different isoforms have been found for this gene. More variants exist, but their full-length natures have yet to be determined. [provided by RefSeq, Dec 2015]
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	154944076 - 154956123
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163346 (version 83.38)
Entrez gene	57326
UniProt	Q96AQ6 (UniProt - Evidence at protein level)
neXtProt	NX_Q96AQ6
Antibodypedia	PBXIP1 antibodies

PROTEIN BROWSER

PBXIP1-001	PBXIP1-003	PBXIP1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PBXIP1-001 ENSP00000357448 ENST00000368463	Q96AQ6 [Direct mapping] Pre-B-cell leukemia transcription factor-interacting protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0007275 [multicellular organismal development] GO:0030154 [cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	731 aa 80.6 kDa	No	1
PBXIP1-003 ENSP00000357450 ENST00000368465	Q96AQ6 [Direct mapping] Pre-B-cell leukemia transcription factor-interacting protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0007275 [multicellular organismal development] GO:0030154 [cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	702 aa 77.7 kDa	No	1
PBXIP1-006 ENSP00000357445 ENST00000368460	Q5T173 [Direct mapping] Pre-B-cell leukemia transcription factor-interacting protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		315 aa 33.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.