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PYGO2

GENERAL INFORMATION

Gene name

 PYGO2

Gene description

 Pygopus family PHD finger 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA023689
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and urothelial cancer (favourable).
Liver cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA023689

GENE INFORMATION

Gene name

 PYGO2

Synonyms

Description

 Pygopus family PHD finger 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 154957026 - 154963853

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163348 (version 83.38)

Entrez gene

 90780

UniProt

 Q9BRQ0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BRQ0

Antibodypedia

 PYGO2 antibodies

PROTEIN BROWSER
PYGO2-001
PYGO2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PYGO2-001
ENSP00000357442
ENST00000368457
Q9BRQ0 [Direct mapping]
Pygopus homolog 2
Q5T170 [Target identity:100%; Query identity:100%]
Pygopus homolog 2 (Drosophila), isoform CRA_a; cDNA FLJ35070 fis, clone PLACE5000139
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001701 [in utero embryonic development]
GO:0001822 [kidney development]
GO:0002088 [lens development in camera-type eye]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0007286 [spermatid development]
GO:0007289 [spermatid nucleus differentiation]
GO:0007420 [brain development]
GO:0008270 [zinc ion binding]
GO:0009791 [post-embryonic development]
GO:0016055 [Wnt signaling pathway]
GO:0030879 [mammary gland development]
GO:0033599 [regulation of mammary gland epithelial cell proliferation]
GO:0035034 [histone acetyltransferase regulator activity]
GO:0035065 [regulation of histone acetylation]
GO:0035563 [positive regulation of chromatin binding]
GO:0042393 [histone binding]
GO:0048589 [developmental growth]
GO:0051569 [regulation of histone H3-K4 methylation]
GO:0060021 [palate development]
GO:0060070 [canonical Wnt signaling pathway]
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 406 aa
41.2 kDa 		No 0
PYGO2-002
ENSP00000357441
ENST00000368456
Q5T171 [Direct mapping]
Pygopus homolog 2; Pygopus homolog 2 (Drosophila), isoform CRA_b
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
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 369 aa
37.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.