Expression of DCST1 in cancer - Summary - The Human Protein Atlas

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DCST1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DCST1
Gene description	DC-STAMP domain containing 1
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Mixed
HPA (normal tissue):	Group enriched (skin, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA060314
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA060314

GENE INFORMATION
Gene name	DCST1 (HGNC Symbol)
Synonyms	FLJ32785
Description	DC-STAMP domain containing 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with a domain similar to one found in dendritic cells (PMID:11169400) which play a key role in antigen processing and display for immune responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	155033824 - 155050930
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163357 (version 83.38)
Entrez gene	149095
UniProt	Q5T197 (UniProt - Evidence at transcript level)
neXtProt	NX_Q5T197
Antibodypedia	DCST1 antibodies

PROTEIN BROWSER

DCST1-001	DCST1-002	DCST1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DCST1-001 ENSP00000295542 ENST00000295542	Q5T197 [Direct mapping] DC-STAMP domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] Show all	706 aa 80.7 kDa	No	7
DCST1-002 ENSP00000357404 ENST00000368419	Q5T197 [Direct mapping] DC-STAMP domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] Show all	664 aa 75.7 kDa	No	7
DCST1-006 ENSP00000387369 ENST00000423025	Q5T197 [Direct mapping] DC-STAMP domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] Show all	681 aa 77.7 kDa	No	6

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.