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APOA1BP

GENERAL INFORMATION

Gene name

 APOA1BP

Gene description

 Apolipoprotein A-I binding protein

Protein class

 Enzymes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA043766 , HPA048164
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA043766
HPA048164

GENE INFORMATION

Gene name

 APOA1BP (HGNC Symbol)

Synonyms

 AIBP, MGC119143, MGC119144, MGC119145, YJEFN1

Description

 Apolipoprotein A-I binding protein (HGNC Symbol)

Entrez gene summary

 The product of this gene interacts with apolipoprotein A-I (apoA-I), the major apolipoprotein of high-density lipoproteins (HDLs). It is secreted into some bodily fluids, and its synthesis and secretion are stimulated in vitro by incubating cells with apoA-I. The human genome contains related pseudogenes. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q22

Chromosome location (bp)

 156591762 - 156594299

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163382 (version 83.38)

Entrez gene

 128240

UniProt

 Q8NCW5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NCW5

Antibodypedia

 APOA1BP antibodies

PROTEIN BROWSER
APOA1BP-001
APOA1BP-002
APOA1BP-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
APOA1BP-001
ENSP00000357218
ENST00000368235
Q8NCW5 [Direct mapping]
NAD(P)H-hydrate epimerase
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Enzymes
   ENZYME proteins
   Isomerase
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005929 [cilium]
GO:0006734 [NADH metabolic process]
GO:0006739 [NADP metabolic process]
GO:0008150 [biological_process]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044297 [cell body]
GO:0046872 [metal ion binding]
GO:0051289 [protein homotetramerization]
GO:0052856 [NADHX epimerase activity]
GO:0052857 [NADPHX epimerase activity]
GO:0070062 [extracellular exosome]
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 288 aa
31.7 kDa 		Yes 0
APOA1BP-002
ENSP00000357217
ENST00000368234
Q5T3I3 [Direct mapping]
NAD(P)H-hydrate epimerase
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006734 [NADH metabolic process]
GO:0006739 [NADP metabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0052856 [NADHX epimerase activity]
GO:0052857 [NADPHX epimerase activity]
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 260 aa
28.3 kDa 		Yes 0
APOA1BP-004
ENSP00000357216
ENST00000368233
Q5T3I4 [Direct mapping]
NAD(P)H-hydrate epimerase
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006734 [NADH metabolic process]
GO:0006739 [NADP metabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0052856 [NADHX epimerase activity]
GO:0052857 [NADPHX epimerase activity]
Show all
 245 aa
26.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.