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CCKAR

GENERAL INFORMATION

Gene name

 CCKAR

Gene description

 Cholecystokinin A receptor

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Not detected
HPA (normal tissue):Group enriched (gallbladder, stomach)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 CCKAR

Synonyms

Description

 Cholecystokinin A receptor (HGNC Symbol)

Entrez gene summary

 This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 p15.2

Chromosome location (bp)

 26481400 - 26490462

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163394 (version 83.38)

Entrez gene

 886

UniProt

 P32238 (UniProt - Evidence at protein level)

neXtProt

 NX_P32238

Antibodypedia

 CCKAR antibodies

PROTEIN BROWSER
CCKAR-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCKAR-001
ENSP00000295589
ENST00000295589
P32238 [Direct mapping]
Cholecystokinin receptor type A
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G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
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GO:0001659 [temperature homeostasis]
GO:0001696 [gastric acid secretion]
GO:0001764 [neuron migration]
GO:0002023 [reduction of food intake in response to dietary excess]
GO:0004930 [G-protein coupled receptor activity]
GO:0004951 [cholecystokinin receptor activity]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007409 [axonogenesis]
GO:0007584 [response to nutrient]
GO:0007586 [digestion]
GO:0007631 [feeding behavior]
GO:0009314 [response to radiation]
GO:0009408 [response to heat]
GO:0016021 [integral component of membrane]
GO:0030073 [insulin secretion]
GO:0030157 [pancreatic juice secretion]
GO:0030900 [forebrain development]
GO:0031016 [pancreas development]
GO:0031100 [organ regeneration]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032496 [response to lipopolysaccharide]
GO:0032870 [cellular response to hormone stimulus]
GO:0038188 [cholecystokinin signaling pathway]
GO:0042277 [peptide binding]
GO:0042594 [response to starvation]
GO:0042755 [eating behavior]
GO:0043195 [terminal bouton]
GO:0043266 [regulation of potassium ion transport]
GO:0046883 [regulation of hormone secretion]
GO:0048545 [response to steroid hormone]
GO:0051384 [response to glucocorticoid]
GO:0051924 [regulation of calcium ion transport]
GO:0090274 [positive regulation of somatostatin secretion]
GO:1901652 [response to peptide]
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 428 aa
47.8 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.