Expression of IGFN1 in cancer - Summary - The Human Protein Atlas

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IGFN1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	IGFN1
Gene description	Immunoglobulin-like and fibronectin type III domain containing 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (renal cancer, thyroid cancer)
HPA (cell line):	Cell line enriched (HeLa)
HPA (normal tissue):	Group enriched (endometrium, epididymis, skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in skeletal muscle

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA050415
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (renal cancer, thyroid cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA050415

GENE INFORMATION
Gene name	IGFN1 (HGNC Symbol)
Synonyms	DKFZp434B1231, EEF1A2BP1
Description	Immunoglobulin-like and fibronectin type III domain containing 1 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q32.1
Chromosome location (bp)	201190825 - 201228952
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163395 (version 83.38)
Entrez gene	91156
UniProt	Q86VF2 (UniProt - Evidence at protein level)
neXtProt	NX_Q86VF2
Antibodypedia	IGFN1 antibodies

PROTEIN BROWSER

IGFN1-001	IGFN1-201	IGFN1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IGFN1-001 ENSP00000387975 ENST00000412892	H7BZ61 [Direct mapping] Immunoglobulin-like and fibronectin type III domain-containing protein 1 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	1126 aa 119.6 kDa	No	0
IGFN1-201 ENSP00000295591 ENST00000295591	Q86VF2 [Direct mapping] Immunoglobulin-like and fibronectin type III domain-containing protein 1 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0008150 [biological_process] GO:0030018 [Z disc] Show all	1251 aa 137.8 kDa	No	0
IGFN1-202 ENSP00000334714 ENST00000335211	Q86VF2 [Direct mapping] Immunoglobulin-like and fibronectin type III domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0008150 [biological_process] GO:0030018 [Z disc] Show all	3708 aa 383.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.